Abstract
In vivo bioassay-guided fractionation of the aqueous alcohol extract of the aerial parts
of Bidens pilosa Sch. Bip. var. radiata (Asteraceae) using C57BL/Ks-db/db mice as a model for type 2 diabetes, yielded two known polyacetylenic glucosides,
identified as 2-β-D-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne (1) and 3-β-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne (2). A 3 : 2 mixture of compounds 1 and 2 effected a significant drop in blood glucose.
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Dr. Diana M. Fort
Shaman Pharmaceuticals Inc.
213 E. Grand Ave.
South San Francisco
CA 94080
U.S.A
Email: dfort@shaman.com
Fax: +1-650-794-0408
