DOI:
        10.1055/s-00000058
      
      
        Planta Medica
       
      
        
          
            Ausgabe 01 · 
           Volume 66 · 
           Februar 2000
            
           
           DOI: 10.1055/s-002-719  
          
          
      
      
      
        
      
      
       
    
  
  
        
        
  
  
    
      Accepted Manuscripts
     
  
  
  
    
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        Ausgabe
      
     
  
  
  
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
      
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
    
  
  
    
      Meistgelesen
     
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
        
          
            
              
              
              
                
                  
                    
                    
                      
                          
                          
                            Rapid Communication 
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                            
                          
                          
                          
                          
  
    
      
        3
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Butterweck, Veronika; 
              
            
          
            
              
              Jürgenliemk, Guido; 
              
            
          
            
              
              Nahrstedt, Adolf; 
              
            
          
            
              
              Winterhoff, Hilke: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                            Original Paper 
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                            
                          
                          
                          
                          
  
    
      
        7
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Boonen, Georg; 
              
            
          
            
              
              Pramanik, Aladdin; 
              
            
          
            
              
              Rigler, Rudolf; 
              
            
          
            
              
              Häberlein, Hanns: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        11
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Shimizu, Kuniyoshi; 
              
            
          
            
              
              Kondo  and, Ryuichiro; 
              
            
          
            
              
              Sakai, Kokki: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        16
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Shimizu, Kuniyoshi; 
              
            
          
            
              
              Fukuda, Masayuki; 
              
            
          
            
              
              Kondo  and, Ryuichiro; 
              
            
          
            
              
              Sakai, Kokki: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        20
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Kiyohara, Hiroaki; 
              
            
          
            
              
              Matsumoto and, Tsukasa; 
              
            
          
            
              
              Yamada, Haruki: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        25
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Kimata, Masahiro; 
              
            
          
            
              
              Inagaki and, Naoki; 
              
            
          
            
              
              Nagai, Hiroichi: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        30
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Paulo, Alexandra; 
              
            
          
            
              
              Gomes, Elsa T.; 
              
            
          
            
              
              Steele, Jonathan; 
              
            
          
            
              
              Warhurst, Dave C.; 
              
            
          
            
              
              Houghton, Peter J.: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        35
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Duarte, Juan; 
              
            
          
            
              
              Torres and, Ana Isabel; 
              
            
          
            
              
              Zarzuelo, Antonio: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        40
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Shim, Sang-Bum; 
              
            
          
            
              
              Kim, Nam-Jae; 
              
            
          
            
              
              Kim, Dong-Hyun: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        44
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Konrad, Lutz; 
              
            
          
            
              
              Müller, Hans-Helge; 
              
            
          
            
              
              Lenz, Corinna; 
              
            
          
            
              
              Laubinger, Helge; 
              
            
          
            
              
              Aumüller, Gerhard; 
              
            
          
            
              
              Lichius, Johannes Josef: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        48
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Schmidgall, J.; 
              
            
          
            
              
              Schnetz, E.; 
              
            
          
            
              
              Hensel, A.: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
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              Perry, Nigel B.; 
              
            
          
            
              
              van Klink, John W.; 
              
            
          
            
              
              Burgess, Elaine J.; 
              
            
          
            
              
              Parmenter, Graeme A.: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        57
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Wallaart, T. Eelco; 
              
            
          
            
              
              Pras, Niesko; 
              
            
          
            
              
              Beekman and, Aäron C.; 
              
            
          
            
              
              Quax, Wim J.: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        63
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Laurent, Dominique; 
              
            
          
            
              
              Guella, Graziano; 
              
            
          
            
              
              Roquebert, Marie-France; 
              
            
          
            
              
              Farinole, Fabrice; 
              
            
          
            
              
              Mancini, Ines; 
              
            
          
            
              
              Pietra, Francesco: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
    
      
        67
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Baldé, Aliou M.; 
              
            
          
            
              
              Apers, Sandra; 
              
            
          
            
              
              De Bruyne, Tess E.; 
              
            
          
            
              
              Van Den Heuvel, Hilde; 
              
            
          
            
              
              Claeys, Magda; 
              
            
          
            
              
              Vlietinck, Arnold J.; 
              
            
          
            
              
              Pieters, Luc A. C.: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                            Letter 
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                            
                          
                          
                          
                          
  
  
    
      
        70
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Lee, Byung-Hoon; 
              
            
          
            
              
              Lee, Sang-Jun; 
              
            
          
            
              
              Kang, Tai-Hyun; 
              
            
          
            
              
              Kim, Do-Hoon; 
              
            
          
            
              
              Sohn, Dong-Hwan; 
              
            
          
            
              
              Ko, Geon-Il; 
              
            
          
            
              
              Kim, Youn-Chul: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        72
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Kim*, Youngsoo; 
              
            
          
            
              
              Jang, Dae-Sig; 
              
            
          
            
              
              Park, Si-Hyung; 
              
            
          
            
              
              Yun, Jieun; 
              
            
          
            
              
              Min, Bo-Kyung; 
              
            
          
            
              
              Min, Kyung Rak; 
              
            
          
            
              
              Lee, Hyeong-Kyu: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        74
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Jung, HyunJu; 
              
            
          
            
              
              Sok, Dai-Eun; 
              
            
          
            
              
              Kim, YoungHo; 
              
            
          
            
              
              Min, ByungSun; 
              
            
          
            
              
              Lee, JongPill; 
              
            
          
            
              
              Bae*, KiHwan: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
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              Jeong, Sei-Joon; 
              
            
          
            
              
              Kim, Na-Young; 
              
            
          
            
              
              Kim, Do-Hoon; 
              
            
          
            
              
              Kang, Tai-Hyun; 
              
            
          
            
              
              Ahn, Nyeon-Hyung; 
              
            
          
            
              
              Miyamoto, T.; 
              
            
          
            
              
              Higuchi, R.; 
              
            
          
            
              
              Kim*, Youn-Chul: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
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              Kim, Dong-Seon; 
              
            
          
            
              
              Jeong, Hyeh-Jean; 
              
            
          
            
              
              Bhat, Krishna P. L.; 
              
            
          
            
              
              Park, So-Young; 
              
            
          
            
              
              Kang, Soo-Hyon; 
              
            
          
            
              
              Yoo, Eun-Hwa; 
              
            
          
            
              
              Lee, Minna; 
              
            
          
            
              
              Lee, Hang-Woo; 
              
            
          
            
              
              Krueger, Robert J.; 
              
            
          
            
              
              Kim*, Darrick S. H. L.: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        80
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Chen, Keh-Shaw; 
              
            
          
            
              
              Chang, Ya-Ling; 
              
            
          
            
              
              Teng, Che-Ming; 
              
            
          
            
              
              Chen, Chieh-Fu; 
              
            
          
            
              
              Wu*, Yang-Chang: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        82
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Ubillas, Rosa P.; 
              
            
          
            
              
              Mendez, Christopher D.; 
              
            
          
            
              
              Jolad, Shivanand D.; 
              
            
          
            
              
              Luo, Jian; 
              
            
          
            
              
              King, Steven R.; 
              
            
          
            
              
              Carlson, Thomas J.; 
              
            
          
            
              
              Fort*, Diana M.: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        84
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Bittar, Magali; 
              
            
          
            
              
              Souza, Márcia Maria de; 
              
            
          
            
              
              Yunes, Rosendo A.; 
              
            
          
            
              
              Lento, Rossana; 
              
            
          
            
              
              Monache, Franco Delle; 
              
            
          
            
              
              Filho*, Valdir Cechinel: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        86
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
          
          
            
              
              Razmilic, Iván B.; 
              
            
          
            
              
              Schmeda-Hirschmann*, Guillermo: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        88
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Homma*, Masato; 
              
            
          
            
              
              Minami, Mana; 
              
            
          
            
              
              Taniguchi, Chizu; 
              
            
          
            
              
              Oka, Kitaro; 
              
            
          
            
              
              Morita, Sonoko; 
              
            
          
            
              
              Niitsuma, Tomoyuki; 
              
            
          
            
              
              Hayashi, Toru: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        91
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Hui, Kwok Min; 
              
            
          
            
              
              Wang, Xi Hong; 
              
            
          
            
              
              Xue*, Hong: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        93
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Federici, Elena; 
              
            
          
            
              
              Palazzino, Giovanna; 
              
            
          
            
              
              Nicoletti, Marcello; 
              
            
          
            
              
              Galeffi*, Corrado: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        96
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Menković*, Nebojša; 
              
            
          
            
              
              Šavikin-Fodulović, Katarina; 
              
            
          
            
              
              Momcilović, Ivana; 
              
            
          
            
              
              Grubišić, Dragoljub: