Synlett 2011(5): 725-729  
DOI: 10.1055/s-0030-1259694
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Chemoenzymatic Synthesis of Idesolide from Benzoic Acid

David R. Adamsa, Christian Aichingerb, Jonathan Collinsa, Uwe Rinnerb, Tomas Hudlicky*a
a Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada
Fax: +1(905)9844841; e-Mail: thudlicky@brocku.ca;
b Institute of Organic Chemistry, University of Vienna, Währinger Str. 38, 1090 Vienna, Austria
Further Information

Publication History

Received 20 January 2011
Publication Date:
25 February 2011 (eFirst)

Abstract

Idesolide was synthesized in five steps from benzoic acid by base-catalyzed dimerization of hydroxy keto ester, obtained from diol, the product of the whole-cell fermentation of benzoic acid with R. eutrophus B9.