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Synlett 2011(7): 1038-1042  
DOI: 10.1055/s-0030-1259729
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Aromatic C-H Bond Halogenation Using Lithium Halides as Halogenating Reagents

Yongzhong Lua, Ruiping Wanga, Xixue Qiaoa, Zengming Shen*b
a Department of Chemistry, College of Life and Environment Sciences, Shanghai Normal University, 100 Guilin Road,Shanghai 200234, P. R. of China
b School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road,Shanghai 200240, P. R. of China
Fax: +86(21)54741297; e-Mail: shenzengming@sjtu.edu.cn;
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Publication History

Received 30 November 2010
Publication Date:
10 March 2011 (online)

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Abstract

The copper-catalyzed C-H halogenation of 2-aryl­pyridines containing a variety of electron-withdrawing and electron-donating substituents was described. It is worth noting that cheap and easy-to-handle lithium halides were utilized as the halogen sources.

Key words

copper - C-H activation - halogenation - lithium halide - arylpyridines

    Primary data for this article are available online and can be cited using the following DOI: 10.4125/pd0009th:
  • Primary Data
    • MS data and associated files for the ¹H and ¹³C NMR spectra for the compounds 3a-o are summarized.

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