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Synlett 2011(8): 1154-1156  
DOI: 10.1055/s-0030-1259926
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Isoxazolinyl Spiropyrrolidinediones: 1,3-Dipolar Cycloaddition of 1-Benzyl-3,3-dimethyl-5-methylenepyrrolidin-2,4-dione

Yaser Bathich, Sharifah Edayu binti Syed Monudeen Khan, Ahmad Sazali Hamzah*
Organic Synthesis Laboratory, Institute of Science, Universiti Teknologi Mara, 40450 Shah Alam, Selangor, Malaysia
Fax: +60(3)55443870; e-Mail: bathich@gmail.com; e-Mail: asazali@salam.uitm.edu.my;
Further Information

Publication History

Received 9 February 2011
Publication Date:
29 March 2011 (online)

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Abstract

A simple and highly efficient methodology for the first synthesis of isoxazolinyl spiropyrrolidinedione starting from keto ester, is presented.

Key words

spiroisoxazoline - 1,3-dipolar cycloaddition - spiropyrrolidine-2,4-dione - isoxazolinyl spiropyrrolidinedione - bioactivity

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