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Synlett 2011(11): 1563-1566
DOI: 10.1055/s-0030-1260791
DOI: 10.1055/s-0030-1260791
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New YorkHypervalent Iodine(III)-LiX Combination in Fluoroalcohol Solvent for Aromatic Halogenation of Electron-Rich Arenecarboxylic Acids
Further Information
Received
12 March 2011
Publication Date:
15 June 2011 (online)
Publication History
Publication Date:
15 June 2011 (online)

Abstract
The novel reagent system, PhI(OAc)2-LiX combination in fluoroalcohol solvents, was found to be effective for halodecarboxylation of electron-rich arenecarboxylic acids. The method provided an efficient route to halogenated phenol ether derivatives.
Key words
carboxylic acids - hypervalent iodine - halogenation - fluoroalchol - decarboxylation
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References and Notes
Compound 3b was also obtained as minor product into the iodination of 1a where 3b was not converted to 4b smoothly (<10%) in further iodination reaction [PhI(OAc)2/LiI combination in HFIP].