Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
          
          https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000171.xml
        Dtsch Med Wochenschr 2011; 136(40): 2007-2010
DOI: 10.1055/s-0031-1286381
   DOI: 10.1055/s-0031-1286381
Hämatologie & Onkologie | Commentary
Hämatologie© Georg Thieme Verlag KG Stuttgart · New York
Chronische myeloische Leukämie
Chronic myeloid leukemiaFurther Information
            
               
                  
            
         
      
   Publication History
Publication Date:
28 September 2011 (online)

Schlüsselwörter
chronische myeloische Leukämie - Tyrosinkinase-Inhibitoren - Interferon alpha - allogene Stammzelltransplantation - minimale Resterkrankung
Keywords
chronic myeloid leukemia - tyrosine kinase inhibitors - interferon alpha - allogenic stem cell transplantation - minimal residual disease
Literatur
- 1 
            Baccarani M, Cortes J, Pane F. et
            al .
            Chronic myeloid leukemia: an update of concepts
            and management recommendations of European LeukemiaNet. 
            J
            Clin Oncol. 
            2009; 
            27 
            6041-6051 
            
            Reference Ris Wihthout Link
- 2 
            Burchert A, Müller M C, Kostrewa P. et al .
            Sustained molecular response
            with interferon alfa maintenance after induction therapy with imatinib
            plus interferon alfa in patients with chronic myeloid leukemia. 
            J Clin Oncol. 
            2010; 
            28 
            1429-1435 
            
            Reference Ris Wihthout Link
- 3 
            Cortes J E, Baccarani M, Guilhot F. et al .
            Phase III, randomized, open-label study
            of daily imatinib mesylate 400 mg versus 800 mg in
            patients with newly diagnosed, previously untreated chronic myeloid
            leukemia in chronic phase using molecular end points: tyrosine kinase
            inhibitor optimization and selectivity study. 
            J Clin Oncol. 
            2010; 
            28 
            424-430 
            
            Reference Ris Wihthout Link
- 4 
            Cortes J, Hochhaus A, Hughes T, Kantarjian H. 
            Front-line and salvage
            therapies with tyrosine kinase inhibitors and other treatments in
            chronic myeloid leukemia. 
            J Clin Oncol. 
            2011; 
            29 
            524-531 
            
            Reference Ris Wihthout Link
- 5 
            Hasford J, Baccarani M, Hoffmann V. et al .
            Predicting complete cytogenetic response and
            subsequent progression-free survival in 2060 patients with CML on
            imatinib treatment: the EUTOS score. 
            Blood. 
            2011; 
            118 
            686-692 
            
            Reference Ris Wihthout Link
- 6 
            Hehlmann R, Lauseker M, Jung-Munkwitz S. et al .
            Tolerability-adapted imatinib 800 mg/d
            versus 400 mg/d versus 400 mg/d
            plus interferon-a in newly diagnosed chronic myeloid leukemia. 
            J Clin Oncol. 
            2011; 
            29 
            1634-1642 
            
            Reference Ris Wihthout Link
- 7 
            Hochhaus A, La Rosée P, Müller M C, Ernst T, Cross N C. 
            Impact of BCR-ABL mutations on patients
            with chronic myeloid leukemia. 
            Cell Cycle. 
            2011; 
            10 
            250-260 
            
            Reference Ris Wihthout Link
- 8 
            Hughes T P, Hochhaus A, Branford S. et al .
            Long-term prognostic significance of early molecular
            response to imatinib in newly diagnosed chronic myeloid leukemia:
            an analysis from the International Randomized Study of Interferon
            and STI571 (IRIS). 
            Blood. 
            2010; 
            116 
            3758-3765 
            
            Reference Ris Wihthout Link
- 9 
            Kantarjian H, Shah N P, Hochhaus A. et al .
            Dasatinib versus imatinib in newly diagnosed chronic-phase
            chronic myeloid leukemia. 
            N Engl J Med. 
            2010; 
            362 
            2260-2270 
            
            Reference Ris Wihthout Link
- 10 
            Mahon F X, Réa D, Guilhot J. et al .
            Discontinuation of imatinib in patients
            with chronic myeloid leukaemia who have maintained complete molecular
            remission for at least 2 years: the prospective, multicentre Stop
            Imatinib (STIM) trial. 
            Lancet Oncol. 
            2010; 
            11 
            1029-1035 
            
            Reference Ris Wihthout Link
- 11 
            Marin D, Bazeos A, Mahon F X. et al .
            Adherence is the critical factor for achieving molecular
            responses in patients with chronic myeloid leukemia who achieve
            complete cytogenetic responses on imatinib. 
            J Clin Oncol. 
            2010; 
            28 
            2381-2388 
            
            Reference Ris Wihthout Link
- 12 
            Müller M C, Cross N C, Erben P. et al .
            Harmonization of molecular
            monitoring of CML therapy in Europe. 
            Leukemia. 
            2009; 
            23 
            1957-1963 
            
            Reference Ris Wihthout Link
- 13 
            Preudhomme C, Guilhot J, Nicolini F E. et al .
            Imatinib plus peginterferon alfa-2a in chronic
            myeloid leukemia. 
            N Engl J Med. 
            2010; 
            363 
            2511-2521 
            
            Reference Ris Wihthout Link
- 14 
            Saglio G, Kim D W, Issaragrisil S. et al .
            Nilotinib versus imatinib for newly diagnosed chronic
            myeloid leukemia. 
            N Engl J Med. 
            2010; 
            362 
            2251-2259 
            
            Reference Ris Wihthout Link
- 15 
            Simonsson B, Gedde-Dahl T, Markevärn B. et al .
            Combination of pegylated
            interferon-a2b with imatinib increases molecular response rates
            in patients with low or intermediate risk chronic myeloid leukemia. 
            Blood. 
            2011 Jun 17 ; 
            [Epub ahead of
            print] 
            
            Reference Ris Wihthout Link
Prof. Dr. Andreas Hochhaus
         Universitätsklinikum Jena
Klinik
         für Innere Medizin II, 
Abteilung Hämatologie
         und internistische Onkologie
         
         Erlanger Allee
         101
         
         07740 Jena
         
         Phone: 03641/932
         4201
         
         Fax: 03641/932 4202
         
         Email: andreas.hochhaus@med.uni-jena.de
         
         
 
    