Synlett 2011(18): 2648-2651  
DOI: 10.1055/s-0031-1289292
© Georg Thieme Verlag Stuttgart ˙ New York

Syngas-Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of Styrenes

Sivarajan Kasinathana, Samuel L. Bourneb, Päivi Tolstoyb, Peter Koosb, Matthew O’Brienb, Roderick W. Batesa, Ian R. Baxendaleb, Steven V. Ley*ba Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371 Singapore, Singapore
b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
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Publication History

Received 19 August 2011
Publication Date:
07 October 2011 (eFirst)


We report a continuous flow, rhodium-catalysed hydroformylation of various styrenes using a tube-in-tube gas-liquid reactor. The flow process afforded selectively branched aryl aldehydes in good yields.