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Synlett 2012(6): 920-924  
DOI: 10.1055/s-0031-1290610
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

An Efficient One-Pot Access to Quinazolinone Derivatives Using TiO2 Nanoparticles as Catalyst: Synthesis and Vasorelaxant Activity Evaluation

Ali Khalafi-Nezhad*a, Saghar Mowlazadeh Haghighia, Azar Purkhosrowb, Farhad Panahi*a
a Chemistry, Shiraz University, Shiraz 71454, Iran
Fax: +98(711)2280926; e-Mail: khalafi@chem.susc.ac.ir; e-Mail: panahi@shirazu.ac.ir;
b Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71454, Iran
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Publikationsverlauf

Received 11 December 2011
Publikationsdatum:
15. März 2012 (online)

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Abstract

A variety of quinazolinone derivatives were successfully synthesized, via a three-component condensation reaction between anthranilic acid, acetic anhydride, and amines. This process was accomplished in the presence of catalytic amount of titanium dioxide nanoparticles (nano-TiO2), under solvent-free conditions. The synthesized compounds were evaluated for their vasorelaxant activity as they revealed a range of activities on the isolated thoracic rat aorta.

Key words

quinazolinone - multicomponent reaction - TiO2 nanoparticles - heterogeneous catalyst - vasorelaxant activity

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