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Arzneimittelforschung 2008; 58(01): 35-41
DOI: 10.1055/s-0031-1296464
Antibiotics · Antimycotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Utility of 4-(5,5-Dimethyl-3-oxo-cyclohex-l-enylamino)benzenesulfonamide in the Synthesis of Novel Quinolines as Possible Anticancer and Radioprotective Agents

Mostafa M. Ghorab
1   Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt
,
Fatma A. Ragab
2   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
,
Eman Noaman
3   Department of Radiation Biology, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt
,
Helmy I. Heiba
1   Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt
,
Ebaa M. El-Hossary
1   Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
15. Dezember 2011 (online)

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Abstract

The present work reports the possible utility of 4-(5,5-dimethyl-3-oxo-cyclohex-1-enylamino)benzenesulfonamide in the synthesis of some novel 4-(quinolin-l-yl) benzenesulfonamide derivatives (6a-o). Structures of the newly synthesized compounds were confirmed by elemental analyses and spectral data. All the newly synthesized compounds were evaluated for their in vitro anticancer activity. Compounds 6k, 6j) and 6m showed interesting cytotoxic activity compared with doxorubicin (CAS 23214-92-8) as a reference drug. Additionally, compound 6c exhibited in vivo radioprotective activity, against γ-irradiation, in mice.

Key words

Anticancer drugs - Quinolines, anticancer activity, radioprotective activity, sulfonamide moiety - Radioprotective drugs - Sulfonamides
 

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