Arzneimittelforschung 1999; 49(10): 853-857
DOI: 10.1055/s-0031-1300514
Antibacterials · Antibiotics · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Antimicrobial Activity of Some New Flavonyl Oxime Ether Derivatives

Meral Tuncçbilek
a  Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogˇ an, Ankara, Turkey
,
Oya Bozdagˇ
a  Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogˇ an, Ankara, Turkey
,
Gülgün Ayhan-Kılcıgil
a  Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogˇ an, Ankara, Turkey
,
Nurten Altanlar
b  Department of Microbiology, Faculty of Pharmacy, Ankara University, Tandogˇ an, Ankara, Turkey
,
Erdem Buyukbingol
a  Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogˇ an, Ankara, Turkey
,
Rahmiye Ertan
a  Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogˇ an, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

Publication Date:
28 December 2011 (online)

Summary

The synthesis of a series of 6 compounds related to 2-(4’-formyl-phenyl)-4H-1-benzopyran-4- one O-substituted oxime and the results of a study of their biological activity are reported. The structural assignments of the compounds is based upon various spectral data. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. Compound F3 exhibited the best antifungal activity compared with ketoconazole and fluconazole.

Zusammenfassung

Synthese und antimikrobielle Aktivität neuer Flavonyl-Oximether-Derivate

Die Synthese einer Reihe von 6 Verbindungen O-substituierter Oxime der 2-(4’-Formylphenyl)-4H-1-benzopyran-4-one und die Ergebnisse von Studien zu ihrer biologischen Wirkung werden berichtet. Die Strukturbestimmung der Substanzen beruht auf spektralen Ergebnissen. Die synthetisierten Substanzen wurden in vitro auf ihre antibakterielle und antimykotische Wirkung untersucht. Die Substanz F3 zeigte die beste antimykotische Aktivität im Vergleich zu Ketoconazol und Fluconazol.