AJP Rep 2012; 02(01): 025-028
DOI: 10.1055/s-0031-1300968
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Five Cases of Congenital Chylothorax Treated by Intrapleural Minocycline

Masatoshi Kaneko
1   Department of Pediatrics, Fukushima Medical University, Fukushima City, Fukushima, Japan
,
Yuji Kanai
1   Department of Pediatrics, Fukushima Medical University, Fukushima City, Fukushima, Japan
,
Hayato Go
1   Department of Pediatrics, Fukushima Medical University, Fukushima City, Fukushima, Japan
,
Takashi Imamura
1   Department of Pediatrics, Fukushima Medical University, Fukushima City, Fukushima, Japan
,
Nobuo Momoi
1   Department of Pediatrics, Fukushima Medical University, Fukushima City, Fukushima, Japan
,
Mitsuaki Hosoya
1   Department of Pediatrics, Fukushima Medical University, Fukushima City, Fukushima, Japan
› Author Affiliations
Further Information

Publication History

20 June 2011

03 October 2011

Publication Date:
30 January 2012 (online)

Abstract

Minocycline pleurodesis was performed on five infants with congenital chylothorax in our institutions. They could not achieve sufficient efficacy though they had received other conservative therapies. Four of the five cases obtained reduction of pleural effusion using the minocycline pleurodesis. We concluded that minocycline pleurodesis is a safe and an effective technique for congenital chylothorax.

 
  • References

  • 1 Lahmiti S, Elhoudzi J, Aboussad A. Congenital chylothorax. Scientific World Journal 2009; 9: 431-434
  • 2 Gaede C. Congenital chylothorax: a case study. Neonatal Netw 2006; 25 (5) 371-381
  • 3 Chen JS, Hsu HH, Chen RJ , et al. Additional minocycline pleurodesis after thoracoscopic surgery for primary spontaneous pneumothorax. Am J Respir Crit Care Med 2006; 173 (5) 548-554
  • 4 Büttiker V, Fanconi S, Burger R. Chylothorax in children: guidelines for diagnosis and management. Chest 1999; 116 (3) 682-687
  • 5 McGrath EE, Blades Z, Anderson PB. Chylothorax: aetiology, diagnosis and therapeutic options. Respir Med 2010; 104 (1) 1-8
  • 6 Wasmuth-Pietzuch A, Hansmann M, Bartmann P, Heep A. Congenital chylothorax: lymphopenia and high risk of neonatal infections. Acta Paediatr 2004; 93 (2) 220-224
  • 7 Maayan-Metzger A, Sack J, Mazkereth R, Vardi A, Kuint J. Somatostatin treatment of congenital chylothorax may induce transient hypothyroidism in newborns. Acta Paediatr 2005; 94 (6) 785-789
  • 8 Bulbul A, Okan F, Nuhoglu A. Idiopathic congenital chylothorax presented with severe hydrops and treated with octreotide in term newborn. J Matern Fetal Neonatal Med 2009; 22 (12) 1197-1200
  • 9 Das A, Shah PS. Octreotide for the treatment of chylothorax in neonates. Cochrane Database Syst Rev 2010; 8 (9, Issue 9) CD006388
  • 10 Roehr CC, Jung A, Proquitté H , et al. Somatostatin or octreotide as treatment options for chylothorax in young children: a systematic review. Intensive Care Med 2006; 32 (5) 650-657
  • 11 Dryzer SR, Joseph J, Baumann M, Birmingham K, Sahn SA, Strange C. Early inflammatory response of minocycline and tetracycline on the rabbit pleura. Chest 1993; 104 (5) 1585-1588
  • 12 Turan O, Canter B, Ergenekon E, Koç E, Atalay Y. Chylothorax and respiratory distress in a newborn with trisomy 21. Eur J Pediatr 2001; 160 (12) 744-745