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Clin Colon Rectal Surg 2012; 25(02): 067-082
DOI: 10.1055/s-0032-1313777
DOI: 10.1055/s-0032-1313777
Identification of Patients at Risk for Hereditary Colorectal Cancer
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
30. Mai 2012 (online)
Abstract
Diagnosis of hereditary colorectal cancer syndromes requires clinical suspicion and knowledge of such syndromes. Lynch syndrome is the most common cause of hereditary colorectal cancer. Other less common causes include familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome (PJS), juvenile polyposis syndrome, and others. There have been a growing number of clinical and molecular tools used to screen and test at risk individuals. Screening tools include diagnostic clinical criteria, family history, genetic prediction models, and tumor testing. Patients who are high risk based on screening should be referred for genetic testing.
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