Challenges and Strategies to the Total Syntheses of Fawcettimine-Type and Serratinine-Type Lycopodium Alkaloids

Xiaoming Wang; Houhua Li; Xiaoguang Lei

doi:10.1055/s-0032-1316912

Synlett, Table of Contents

Synlett 2013; 24(9): 1032-1043
DOI: 10.1055/s-0032-1316912

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Challenges and Strategies to the Total Syntheses of Fawcettimine-Type and Serratinine-Type Lycopodium Alkaloids

Xiaoming Wang

^aCollege of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. of China

,

Houhua Li

^bNational Institute of Biological Sciences (NIBS), Beijing 102206, P. R. of China Fax: +86(10)80704785 Email: leixiaoguang@nibs.ac.cn

,

Xiaoguang Lei*

^aCollege of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. of China

^bNational Institute of Biological Sciences (NIBS), Beijing 102206, P. R. of China Fax: +86(10)80704785 Email: leixiaoguang@nibs.ac.cn

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Abstract

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Abstract

The fawcettimine- and serratinine-type lycopodium alkaloids are a series of structurally complex but related natural products. These alkaloids have been the subjects of intense studies by the synthetic chemistry community, and many elegant strategies have been developed. Herein, we describe the recently disclosed synthetic strategies towards this unique family of natural products, in particular the synthetic endeavors from our research laboratory.

Key words

total synthesis - fawcettimine - serratinine - lycopodium alkaloid - biosynthesis - collective synthesis - ring-chain tautomerism

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References

References and Notes

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