Synlett 2013; 24(4): 408-411
DOI: 10.1055/s-0032-1317866
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© Georg Thieme Verlag Stuttgart · New York

Development and Challenges in Copper-Catalyzed Asymmetric Ullmann-Type Coupling Reactions

Qian Cai*
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou Science Park, ­Guangzhou, 510530, P. R. of China   Fax: +86(20)32290606   Email: cai_qian@gibh.ac.cn
,
Fengtao Zhou
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou Science Park, ­Guangzhou, 510530, P. R. of China   Fax: +86(20)32290606   Email: cai_qian@gibh.ac.cn
› Author Affiliations
Further Information

Publication History

Received: 16 October 2012

Accepted after revision: 21 November 2012

Publication Date:
10 December 2012 (online)

Abstract

Ullmann-type coupling is one of the most powerful methods for the formation of aryl C–C, C–N, and C–O bonds. Yet asymmetric Ullmann coupling has received little attention because of the great challenges in both ligand and reaction designs. The success of the first catalytic enantioselective intramolecular Ullmann C–N coupling reaction through an asymmetric desymmetrization strategy offers a new way to develop enantioselective variants of such reactions. This paper addresses the importance of the desymmetrization strategy in Ullmann-type couplings and outlines some future directions in this field.

 
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