A series of phthalazinedione bearing substituted oxadiazole moiety derivatives X(1–7)
were synthesized in good yield and evaluated for their possible anticonvulsant activity.
The structures of the synthesized compounds were confirmed on the basis of their spectral
data and elemental analysis. Their anticonvulsant activities were evaluated by the
maximal electroshock induced seizure (MES) and subcutaneous pentylenetetrazole (PTZ)
tests. All the tested compounds showed considerable anticonvulsant activities in at
least one of the anticonvulsant tests. Moreover, some of the tested compounds exhibited
moderate anticonvulsant activities in both MES and PTZ tests. From these results,[3-)2-Alkoxycarbonylmethylthioxadiozol-5-yl)methyl
-6-Iodophthalazine – 1,4- (2H,3H)-1,4-dion] (X1–7) derivatives could be recommended
as novel structures of broad spectrum anticonvulsants.
Key words
antiepleptics - phthalazinedione - 1, 3, 4-oxadiazole