Manifestation internistischer Erkrankungen im Larynx: Chronisch entzündliche Erkrankungen

A. Pickhard; E. Smith; R. Rottscholl; S. Brosch; R. Reiter

doi:10.1055/s-0032-1323769

Laryngo-Rhino-Otologie, Table of Contents

Laryngorhinootologie 2012; 91(12): 758-766
DOI: 10.1055/s-0032-1323769

Übersicht

Manifestation internistischer Erkrankungen im Larynx: Chronisch entzündliche Erkrankungen

Disorders of the Larynx and Chronic Inflammatory Diseases

A. Pickhard

¹HNO, Technische Universität München, München

,

E. Smith

²HNO, Sektion Phoniatrie, Univ.-Klinik Ulm, Ulm

,

R. Rottscholl

³Institut für Pathologie, Univ.-Klinik Ulm, Ulm

,

S. Brosch

²HNO, Sektion Phoniatrie, Univ.-Klinik Ulm, Ulm

,

R. Reiter

²HNO, Sektion Phoniatrie, Univ.-Klinik Ulm, Ulm

› Author Affiliations

Abstract

Zusammenfassung

Chronisch entzündliche Erkrankungen wie die Tuberkulose, Erkrankungen aus dem rheumatischen Formenkreis (Rheumatoide Arthritis, Sarkoidose, Systemischer Lupus Erythematodes, Wegener Granulomatose, Relapsing Polychondritis) und die Refluxerkrankung sind üblicherweise systemische internistische Erkrankungen, können sich jedoch auch lokal im Larynx manifestieren. Das klinische Erscheinungsbild ist häufig unspezifisch, was die Diagnose oft erschwert bzw. deutlich verzögert. Differenzialdiagnostisch kommen auch solide oder hämatologische Malignome in Frage, weshalb zur Diagnosesicherung häufig eine Probeexzision erfolgen muss. Die Therapie solcher Erkrankungen erfolgt üblicherweise in enger Zusammenarbeit mit den Internisten.

Abstract

Disorders of the Larynx and Chronic Inflammatory Diseases

Chronic inflammatory diseases including tuberculosis, rheumatic disorders (rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, Wegeners’s granulomatosis, relapsing polychondritis) and reflux disease are considered as systemic diseases, and may affect the larynx. The clinical symptoms are often unspecific, leading to prolonged intervals to diagnosis. Solid and haematological tumours should be considered in differential diagnosis and may require bioptic sampling. Treatment may require interdisciplinary approach.

Schlüsselwörter

Larynx - rheumatische Erkrankungen - Reflux - Sarkoidose - Karzinom

Key words

larynx - rheumatic disorders - reflux - sarcoidosis - carcinoma

Full Text

References

Literatur
1 Schröck A, Göke F, Jakob M, Eichhorn K, Huss S, Bootz F, Gerstner AO. Initial diagnosis of head and neck tuberculosis. Laryngorhinootologie 2011; 90 (10) 604-608
2 Reiter R, Stier KH, Brosch S. Hoarseness in patient with systemic lupus erythematosus. Laryngorhinootologie 2011; 90 (04) 226-227
3 Murano E, Hosako-Naito Y, Tayama N, Oka T, Miyaji M, Kumada M, Niimi S. Bamboo node: primary vocal fold lesion as evidence of autoimmune disease. J Voice 2001; 15 (03) 441-450
4 Hughes M, Hill J. Left vocal cord paralysis in systemic lupus erythematosus. Mod Rheumatol 2009; 19 (04) 441-442
5 Peters JE, Salama AD, Ind PW. Wegener’s granulomatosis presenting as acute systemic vasculitis following 20 years of limited tracheobronchial disease. J Laryngol Otol 2009; 23 (12) 1375-1377
6 Mrówka-Kata K, Kata D, Lange D, Namysłowski G, Czecior E, Banert K. Sarcoidosis and its otolaryngological implications. Eur Arch Otorhinolaryngol 2010; 267 (10) 1507-1514
7 Loehrl TA, Smith TL. Inflammatory and granulomatous lesions of the larynx and pharynx. Am J Med 2001; 111 (8A) 113S-117S
8 Altman KW, Prufer N, Vaezi MF. A review of clinical practice guidelines for reflux disease: toward creating a clinical protocol for the otolaryngologist. Laryngoscope 2011; 121 (04) 717-723
9 Rizzo PB, Da Mosto MC, Clari M, Scotton PG, Vaglia A, Marchiori C. Laryngeal tuberculosis: an often forgotten diagnosis. Int J Infect Dis 2003; 7 (02) 129-131
10 Gottschlich S, Ambrosch P, Kramkowski D, Laudien M, Buchelt T, Gross WL, Hellmich B. Head and neck manifestations of Wegener’s granulomatosis. Rhinology 2006; 44 (04) 227-233
11 Vaezi MF, Qadeer MA, Lopez R, Colabianchi N. Laryngeal cancer and gastroesophageal reflux disease: a case-control study. Am J Med 2006; 119 (09) 768-776
12 Porras Alonso E, Martín Mateos A, Perez-Requena J, Avalos Serrano E. Laryngeal tuberculosis. Rev Laryngol Otol Rhinol (Bord) 2002; 123 (01) 47-48
13 Wang CC, Lin CC, Wang CP, Liu SA, Jiang RS. Laryngeal tuberculosis: a review of 26 cases. Otolaryngol Head Neck Surg 2007; 37 (04) 582-588
14 Singh B, Balwally AN, Nash M, Har-El G, Lucente FE. Laryngeal tuberculosis in HIV-infected patients: a difficult diagnosis. Laryngoscope 1996; 106 (10) 1238-1240
15 Lim JY, Kim KM, Choi EC, Kim YH, Kim HS, Choi HS. Current clinical propensity of laryngeal tuberculosis: review of 60 cases. Eur Arch Otorhinolaryngol 2006; 263 (09) 838-842
16 Nalini B, Vinayak S. Tuberculosis in ear, nose, and throat practice: its presentation and diagnosis. Am J Otolaryngol 2006; 27 (01) 39-45
17 Williams RG, Douglas-Jones T. Mycobacterium marches back. J Laryngol Otol 1995; 109 (01) 5-13
18 Brodhun B, Altmann D, Haas W. Bericht zur Epidemiologie der Tuberkulose in Deutschland für 2008. www.rki.de
19 Smulders YE, De Bondt BJ, Lacko M, Hodge JA, Kross KW. Laryngeal tuberculosis presenting as a supraglottic carcinoma: a case report and review of the literature. J Med Case Rep 2009; 20 ((3)) 9288
20 El Kettani NE, El Hassani M, Chakir N, Jiddane M. Primary laryngeal tuberculosis mimicking laryngeal carcinoma: CT scan features. Indian J Radiol Imaging 2010; 20 (01) 11-12
21 Ling L, Zhou SH, Wang SQ. Changing trends in the clinical features of laryngeal tuberculosis: a report of 19 cases. Int J Infect Dis 2010; 14 (03) 230-235
22 Shin JE, Nam SY, Yoo SJ, Kim SY. Changing trends in clinical manifestations of laryngeal tuberculosis. Laryngoscope 2000; 110 (11) 1950-1953
23 Herold G. Innere Medizin. Köln: 2011: S1-S576
24 Ramos HV, Pillon J, Kosugi EM, Fujita R, Pontes P. Laryngeal assessment in rheumatic disease patients. Braz J Otorhinolaryngol 2005; 71 (04) 499-503
25 Knopf A, Bas M, Chaker A, Strassen U, Pickhard A, Stark T, Lahmer T, Thürmel K. Rheumatic disorders affecting the head and neck: underestimated diseases. Rheumatology (Oxford) 2011; 50 (11) 2029-3426
26 Brooker DS. Rheumatoid arthritis: otorhinolaryngological manifestations. Clin Otolaryngol Allied Sci 1988; 13 (03) 239-246
27 Voulgari PV, Papazisi D, Bai M, Zagorianakou P, Assimakopoulos D, Drosos AA. Laryngeal involvement in rheumatoid arthritis. Rheumatol Int 2005; 25 (05) 321-325
28 Bayar N, Kara SA, Keleş I, Koç C, Altinok D, Orkun S. Cricoarytenoiditis in rheumatoid arthritis: radiologic and clinical study. J Otolaryngol 2003; 32 (06) 373-378
29 Abdel-Aziz M, Azab NA, Bassyouni IH, Hamdy G. Laryngeal involvement in juvenile idiopathic arthritis patients. Clin Rheumatol 2011; 30 (09) 1251-1256
30 Lawry GV, Finerman ML, Hanafee WN, Mancuso AA, Fan PT, Bluestone R. Laryngeal involvement in rheumatoid arthritis. A clinical, laryngoscopic, and computerized tomographic study. Arthritis Rheum 1984; 27 (08) 873-882
31 Kolman J, Morris I. Cricoarytenoid arthritis: a cause of acute upper airway obstruction in rheumatoid arthritis. Can J Anaesth 2002; 49 (07) 729-732
32 Pathan EM, Oak JL, Jakareddy R, Sathe S, Kejriwal A. Upper airway obstruction due to cricoarytenoid arthritis in a case of systemic onset juvenile rheumatoid arthritis. J Assoc Physicians India 2001; 49: 566-567
33 Kamanli A, Gok U, Sahin S, Kaygusuz I, Ardicoglu O, Yalcin S. Bilateral cricoarytenoid joint involvement in rheumatoid arthritis: a case report. Rheumatology (Oxford) 2001; 40 (05) 593-594
34 Eckel HE, Wittekindt C, Klussmann JP, Schroeder U, Sittel C. Management of bilateral arytenoid cartilage fixation versus recurrent laryngeal nerve paralysis. Ann Otol Rhinol Laryngol 2003; 112 (02) 103-108
35 Sørensen WT, Møller-Andersen K, Behrendt N. Rheumatoid nodules of the larynx. J Laryngol Otol 1998; 112 (06) 573-574
36 Teitel AD, MacKenzie CR, Stern R, Paget SA. Laryngeal involvement in systemic lupus erythematosus. Semin Arthritis Rheum 1992; 22 (03) 203-214
37 Hilgert E, Toleti B, Kruger K, Nejedlo I. Hoarseness due to bamboo nodes in patients with autoimmune diseases: a review of literature. J Voice 2008; 22 (03) 343-350
38 Schwemmle C, Kreipe HH, Witte T, Ptok M. Bamboo nodes associated with mixed connective tissue disease as a cause of hoarseness. Rheumatol Int 2011; Nov 16, accepted
39 Schwemmle C, Ptok M. Bamboo nodes as the cause of dysphonias in autoimmune diseases. HNO 2007; 55 (07) 564-568
40 Cannady SB, Batra PS, Koening C, Lorenz RR, Citardi MJ, Langford C, Hoffman GS. Sinonasal Wegener granulomatosis: a single-institution experience with 120 cases. Laryngoscope 2009; 119 (04) 757-761
41 Wittekindt C, Lüers JC, Drebber U, Guntinas-Lichius O, Hüttenbrink KB. ANCA-negative subglottic laryngeal stenosis in childhood. HNO 2007; 55 (10) 807-811
42 Belostotsky VM, Shah V, Dillon MJ. Clinical features in 17 paediatric patients with Wegener granulomatosis. Pediatr Nephrol 2002; 17 (09) 754-761
43 Blaivas AJ, Strauss W, Yudd M. Subglottic stenosis as a complication of Wegener’s granulomatosis. Prim Care Respir J 2008; 17 (02) 114-116
44 Gluth MB, Shinners PA, Kasperbauer JL. Subglottic stenosis associated with Wegener’s granulomatosis. Laryngoscope 2003; 113 (08) 1304-1307
45 Belloso A, Estrach C, Keith AO. Supraglottic stenosis in localized Wegener granulomatosis. Ear Nose Throat J 2008; 87 (07) E11-E14
46 Morgenthau AS, Teirstein AS. Sarcoidosis of the upper and lower airways. Expert Rev Respir Med 2011; 5 (06) 823-833
47 Schwartzbauer HR, Tami TA. Ear, nose, and throat manifestations of sarcoidosis. Otolaryngol Clin North Am 2003; 36 (04) 673-684
48 Baughman RP, Lower EE, du Bois RM. Sarcoidosis. Lancet 2003; 361 (9363) 1111-1118
49 Dean CM, Sataloff RT, Hawkshaw MJ, Pribikin E. Laryngeal sarcoidosis. J Voice 2002; 16 (02) 283-288
50 Gallivan GJ, Landis JN. Sarcoidosis of the larynx: preserving and restoring airway and professional voice. J Voice 1993; 7 (01) 81-94
51 Bower JS, Belen JE, Weg JG, Dantzker DR. Manifestations and treatment of laryngeal sarcoidosis. Am Rev Respir Dis 1980; 122 (02) 325-332
52 Fortune S, Courey MS. Isolated laryngeal sarcoidosis. Otolaryngol Head Neck Surg 1998; 118 (06) 868-870
53 James JC, Simpson CB. Treatment of laryngeal sarcoidosis with CO2 laser and mitomycin-C. Otolaryngol Head Neck Surg 2004; 130 (02) 262-264
54 Neel 3rd HB, McDonald TJ. Laryngeal sarcoidosis: report of 13 patients. Ann Otol Rhinol Laryngol 1982; 91 (4 Pt 1) 359-362
55 Davis C, Girzadas Jr DV. Laryngeal sarcoidosis causing acute upper airway obstruction. Am J Emerg Med 2008; 26 (01) 1-3
56 Yanardağ H, Enoz M, Papila I, Uygun S, Caner M, Karayel T. Upper respiratory tract involvement of sarcoidosis in the Turkish population. Otolaryngol Head Neck Surg 2006; 134 (05) 848-851
57 Plaschke CC, Owen HH, Rasmussen N. Clinically isolated laryngeal sarcoidosis. Eur Arch Otorhinolaryngol 2011; 268 (04) 575-804
58 Trentham DE, Le CH. Relapsing polychondritis. Ann Intern Med 1998; 129 (02) 114-122
59 Kim CM, Kim BS, Cho KJ, Hong SJ. Laryngotracheal involvement of relapsing polychondritis in a Korean girl. Pediatr Pulmonol 2003; 35 (04) 314-317
60 Woodbury K, Smith LJ. Relapsing polychondritis: a rare etiology of dysphonia and novel approach to treatment. Laryngoscope 2011; 121 (05) 1006-1008
61 Karaiskaki N, Mann WJ. Subglottic tracheal stenosis. HNO 2012; 60 (06) 505-510
62 Karaman E, Duman C, Cansz H, Ylmaz M, Ibrahimov M. Laryngotracheal reconstruction at relapsing polychondritis. J Craniofac Surg 2010; 21 (01) 211-212
63 McAdam LP, O’Hanlan MA, Bluestone R, Pearson CM. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore) 1976; 55 (03) 193-215
64 Schreiber S, Garten D, Sudhoff H. Pathophysiological mechanisms of extraesophageal reflux in otolaryngeal disorders. Eur Arch Otorhinolaryngol 2009; 266 (01) 17-24
65 Kotby MN, Hassan O, El-Makhzangy AM, Farahat M, Milad P. Gastroesophageal reflux/laryngopharyngeal reflux disease: a critical analysis of the literature. Eur Arch Otorhinolaryngol 2010; 267 (02) 171-179
66 Groome M, Cotton JP, Borland M, McLeod S, Johnston DA, Dillon JF. Prevalence of laryngopharyngeal reflux in a population with gastroesophageal reflux. Laryngoscope 2007; 117 (08) 1424-1428
67 Li YM, Du J, Zhang H, Yu CH. Epidemiological investigation in outpatients with symptomatic gastroesophageal reflux from the Department of Medicine in Zhejiang Province, east China. J Gastroenterol Hepatol 2008; 23 (02) 283-289
68 Joniau S, Bradshaw A, Esterman A, Carney AS. Reflux and laryngitis: a systematic review. Otolaryngol Head Neck Surg 2007; 136 (05) 686-692
69 Reulbach TR, Belafsky PC, Blalock PD, Koufman JA, Postma GN. Occult laryngeal pathology in a community-based cohort. Otolaryngol Head Neck Surg 2001; 124 (04) 448-450
70 Khan AM, Hashmi SR, Elahi F, Tariq M, Ingrams DR. Laryngopharyngeal reflux: A literature review. Surgeon 2006; 4 (04) 221-225
71 Gupta R, Sataloff RT. Laryngopharyngeal reflux: current concepts and questions. Curr Opin Otolaryngol Head Neck Surg 2009; 17 (03) 143-148
72 Belafsky PC, Rees CJ. Laryngopharyngeal reflux: the value of otolaryngology examination. Curr Gastroenterol Rep 2008; 10 (03) 278-282
73 Johnston N, Bulmer D, Gill GA, Panetti M, Ross PE, Pearson JP, Pignatelli M, Axford SE, Dettmar PW, Koufman JA. Cell biology of laryngeal epithelial defenses in health and disease: further studies. Ann Otol Rhinol Laryngol 2003; 112 (06) 481-491
74 Vaezi MF. Laryngeal manifestations of gastroesophageal reflux disease. Curr Gastroenterol Rep 2008; 10 (03) 271-277
75 Koufman JA. Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease. Ear Nose Throat J Sep 2002; 81 (Suppl. 02) 7-9
76 Saritas Yuksel E, Vaezi MF. Extraesophageal manifestations of gastroesophageal reflux disease: cough, asthma, laryngitis, chest pain. Swiss Med Wkly. 2012; 2;142: 141-148
77 Vaezi MF. Laryngitis and gastroesophageal reflux disease: increasing prevalence or poor diagnostic tests?. Am J Gastroenterol 2004; 99 (05) 786-788
78 Reiter R, Brosch S. Chronic laryngitis – associated factors and voice assessment. Laryngorhinootologie 2009; 88 (03) 181-185
79 Pearson JP, Parikh S, Orlando RC, Johnston N, Allen J, Tinling SP, Johnston N, Belafsky P, Arevalo LF, Sharma N, Castell DO, Fox M, Harding SM, Morice AH, Watson MG, Shields MD, Bateman N, McCallion WA, van Wijk MP, Wenzl TG, Karkos PD, Belafsky PC. Review article: reflux and its consequences – the laryngeal, pulmonary and oesophageal manifestations. Conference held in conjunction with the 9^th International Symposium on Human Pepsin (ISHP) Kingston-upon-Hull, UK, 21–23 April 2010. Aliment Pharmacol Ther 2011; 33 (Suppl. 01) 1-71
80 Devaney KO, Rinaldo A, Ferlito A. Vocal process granuloma of the larynx-recognition, differential diagnosis and treatment. Oral Oncol 2005; 41 (07) 666-669
81 Carroll TL, Gartner-Schmidt J, Statham MM, Rosen CA. Vocal process granuloma and glottal insufficiency: an overlooked etiology?. Laryngoscope 2010; 120 (01) 114-120
82 Farwell DG, Belafsky PC, Rees CJ. An endoscopic grading system for vocal process granuloma. J Laryngol Otol 2008; 122 (10) 1092-1095
83 Halstead LA. Gastroesophageal reflux: A critical factor in pediatric subglottic stenosis. Otolaryngol Head Neck Surg 1999; 120 (05) 683-688
84 Johanson JF. Epidemiology of esophageal and supraesophageal reflux injuries. Am J Med 2000; 108 (4a) 99S-103S
85 Freije JE, Beatty TW, Campbell BH, Woodson BT, Schultz CJ, Toohill RJ. Carcinoma of the larynx in patients with gastroesophageal reflux. Am J Otolaryngol 1996; 17 (06) 386-390
86 Galli J, Cammarota G, Volante M, De Corso E, Almadori G, Paludetti G. Laryngeal carcinoma and laryngo-pharyngeal reflux disease. Acta Otorhinolaryngol Ital 2006; 26 (05) 260-263
87 Franco Jr RA. Laryngopharyngeal reflux. Allergy Asthma Proc 2006; 27 (01) 21-25
88 Qadeer MA, Lopez R, Wood BG, Esclamado R, Strome M, Vaezi MF. Does acid suppressive therapy reduce the risk of laryngeal cancer recurrence?. Laryngoscope Oct 2005; 115 (10) 1877-1881
89 Qadeer MA, Colabianchi N, Strome M, Vaezi MF. Gastroesophageal reflux and laryngeal cancer: causation or association? A critical review. Am J Otolaryngol 2006; 27 (02) 119-128
90 Dağli S, Dağli U, Kurtaran H, Alkim C, Sahin B. Laryngopharyngeal reflux in laryngeal cancer. Turk J Gastroenterol 2004; 15 (02) 77-81
91 Orenstein SR. An overview of reflux-associated disorders in infants: apnea, laryngospasm, and aspiration. Am J Med 2001; 111 (8A) 60S-63S Review
92 Kenn K, Balkissoon R. Vocal cord dysfunction: what do we know?. Eur Respir J 2011; 37 (01) 194-200
93 Balkissoon R. Vocal cord dysfunction, gastroesophageal reflux disease, and nonallergic rhinitis. Clin Allergy Immunol 2007; 19: 411-426
94 Eryuksel E, Dogan M, Golabi P, Sehitoglu MA, Celikel T. Treatment of laryngopharyngeal reflux improves asthma symptoms in asthmatics. J Asthma 2006; 43 (07) 539-542
95 Havemann BD, Henderson CA, El-Serag HB. The association between gastro-oesophageal reflux disease and asthma: a systematic review. Gut 2007; 56 (12) 1654-1664
96 Ahmed TF, Khandwala F, Abelson TI, Hicks DM, Richter JE, Milstein C, Vaezi MF. Chronic laryngitis associated with gastroesophageal reflux: prospective assessment of differences in practice patterns between gastroenterologists and ENT physicians. Am J Gastroenterol Mar 2006; 101 (03) 470-478
97 Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991; 101 (Suppl. 53) 1-78
98 Wiener GJ, Koufman JA, Wu WC, Cooper JB, Richter JE, Castell DO. Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-h ambulatory pH monitoring. Am J Gastroenterol 1989; 84 (12) 1503-1508
99 Schwartz SR, Cohen SM, Dailey SH, Rosenfeld RM, Deutsch ES, Gillespie MB, Granieri E, Hapner ER, Kimball CE, Krouse HJ, McMurray JS, Medina S, O’Brien K, Ouellette DR, Messinger-Rapport BJ, Stachler RJ, Strode S, Thompson DM, Stemple JC, Willging JP, Cowley T, McCoy S, Bernad PG, Patel MM. Clinical practice guideline: hoarseness (dysphonia). Otolaryngol Head Neck Surg 2009; 141 (Suppl. 02) S1-S31
100 Bajbouj M. Diagnosis and therapy of atypical reflux symptoms when PPI therapy fails. HNO 2012; 60 (03) 193-199
101 Katelaris P, Holloway R, Talley N, Gotley D, Williams S, Dent J. Digestive Health Foundation of the Gastroenterological Society of Australia. Gastro-oesophageal reflux disease in adults: Guidelines for clinicians. J Gastroenterol Hepatol 2002; 17 (08) 825-833
102 Koufman JA. Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease. Ear Nose Throat J 2002; 81 (Suppl. 02) 7-9
103 Koufman JA, Amin MR, Panetti M. Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg 2000; 123 (04) 385-388
104 Ptok M, Ptok A. Laryngopharyngeal reflux and larynx-related symptoms. HNO 2012; 60 (03) 200-205
105 Jonaitis L, Pribuisiene R, Kupcinskas L, Uloza V. Laryngeal examination is superior to endoscopy in the diagnosis of the laryngopharyngeal form of gastroesophageal reflux disease. Scand J Gastroenterol 2006; 41 (02) 131-137
106 Vavricka SR, Storck CA, Wildi SM, Tutuian R, Wiegand N, Rousson V, Fruehauf H, Mullhaupt B, Fried M. Limited diagnostic value of laryngopharyngeal lesions in patients with gastroesophageal reflux during routine upper gastrointestinal endoscopy. Am J Gastroenterol 2007; 102 (04) 716-722
107 Jungheim M, Ptok M. Extraesophageal reflux. Overview and discussion of a new method for pH monitoring. HNO 2011; 59 (09) 893-899
108 Maceri DR, Zim S. Laryngospasm: an atypical manifestation of severe gastroesophageal reflux disease (GERD). Laryngoscope 2001; 111 (11 Pt 1) 1976-1979
109 Steward DL, Wilson KM, Kelly DH, Patil MS, Schwartzbauer HR, Long JD, Welge JA. Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo-control trial. Otolaryngol Head Neck Surg 2004; 131 (04) 342-350
110 Fennerty MB, Finke KB, Kushner PR, Peura DA, Record L, Riley L, Ruoff GE, Simonson W, Wright WL. Short- and long-term management of heartburn and other acid-related disorders: development of an algorithm for primary care providers. J Fam Pract 2009; 58 (7 Suppl Short) 1-12
111 Herlyn K, Hellmich B, Gross W, Reinhold-Keller E. Stabile Inzidenz systemischer Vaskulitiden in Schleswig-Holstein. Stable Incidence of Systemic Vasculitides in Schleswig-Holstein. Dtsch Ärztebl 2008; 105 (19) 355-361
112 Alaani A, Hogg RP, Drake Lee AB. Wegener’s granulomatosis and subglottic stenosis: management of the airway. J Laryngol Otol Oct 2004; 118 (10) 786-790