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Int J Sports Med 2013; 34(09): 777-782
DOI: 10.1055/s-0032-1331257
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Marathon Running on Cardiac Markers and Endothelin-1 in EIH Athletes

Y. J. Kim
1   Department of Rehabilitation Medicine, Inje University Paik Hospital, Seoul, Republic of Korea
,
Y. O. Shin
2   Department of Health Care, Graduate school, Soonchunhyang University, Asan, Republic of Korea
,
Y. H. Lee
3   Department of Sports Physiology, Korea National Sport University, Seoul, Republic of Korea
,
H. M. Jee
4   Exercise and Health Management, Namseoul University, Cheonan-si,Republic of Korea
,
K. A. Shin
5   Laboratory Medicine, Bun-dang Je-saeng hospital, Sungnam-si, Republic of Korea
,
C. W. Goh
6   Cardiology, Sanggye-Paik Hospital, Inje University, Seoul, Republic of Korea
,
C. H. Kim
7   Department of Physiology and Biophysics, Eulji University School of ­Medicine, Daejeon-si, Republic of Korea
,
Y. K. Min
8   Department of Physiology, College of Medicine, Soonchunhyang ­University, Cheonan, Republic of Korea
,
H. M. Yang
8   Department of Physiology, College of Medicine, Soonchunhyang ­University, Cheonan, Republic of Korea
,
J. B. Lee
8   Department of Physiology, College of Medicine, Soonchunhyang ­University, Cheonan, Republic of Korea
› Author Affiliations
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Publication History



accepted after revision 15 November 2012

Publication Date:
26 February 2013 (online)

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Effects of Marathon Running on Cardiac Markers and Endothelin-1 in EIH AthletesInt J Sports Med 2013; 34(09): e3-e3
DOI: 10.1055/s-0033-1353208

Abstract

The aim of the present study was to determine the changes in cardiac makers and endothelin-1 (ET-1) in marathoners with exercise induced hypertension compared to normotensive controls before and after running a marathon. Among a total of 70 volunteers, 10 marathoners with systolic blood pressure (SBP) greater than 210 mmHg during a treadmill exercise stress test were selected as an exercise-induced hypertension group (EIH) and 10 marathoners with normal SBP were selected as a control group (CON). Blood was collected from all volunteers 2 h before and immediately after a marathon: creatinine kinase (CK), CK-MB, cardiac tropoin-I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), and endothelin-1(ET-1). Cardiac markers, CK, CK-MB, and CK-MB/CK ratio significantly increased in both EIH and CON; significance was not observed between the groups. Significant increases were not observed in high sensitive-C reactive protein (hs-CRP) after the race nor between the groups. Significant increases in cTnI and NT-proBNP were observed after the race in both groups. In addition, EIH showed greater increase than CON after the race. In conclusion, increased vascular tone in EIH during a marathon increased blood pressure and myocardial burden which in turn increased myocardial cell membrane permeability to further increase myocardial tension to the point of cTnI release.

Key words

hypertension - creatine kinase - cTnI - NT-proBNP
 

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