Psychiatr Prax 2013; 40(05): 248-251
DOI: 10.1055/s-0032-1332949
© Georg Thieme Verlag KG Stuttgart · New York

Diphenhydramin-Abhängigkeit und -Entzug

Systematische Literaturübersicht und ein FallberichtDiphenhydramine Addiction and DetoxificationA Systematic Review and Case Report
Sebastian Erbe
Schlosspark-Klinik, Abteilung Psychiatrie, Berlin
Tom Bschor
Schlosspark-Klinik, Abteilung Psychiatrie, Berlin
› Author Affiliations
Further Information

Publication History

Publication Date:
04 March 2013 (online)


Anliegen: Unsere systematische Literaturübersicht soll auf die Gefahr der Diphenhydramin (DPH)-Abhängigkeit hinweisen.

Methodik: Es erfolgte eine Recherche in Pubmed zwischen 1972 und 2012. Zudem berichten wir von einer Patientin mit DPH-Abhängigkeit.

Ergebnisse: Es ergeben sich gesicherte Hinweise für ein Abhängigkeitspotenzial von DPH.

Schlussfolgerung: Insbesondere bei Patienten mit Abhängigkeitserkrankungen in der Vorgeschichte muss an die Möglichkeit einer DPH-Abhängigkeit gedacht und diese bei Verdacht durch eine gezielte Exploration überprüft werden.


Objective: In many countries diphenhydramine (DPH) is commonly available over the counter, frequently used, and generally regarded as a harmless drug. It is used as a sedative, antiallergic or antiemetic substance.

Methods: We present a systematic review of literature search in Pubmed from 1972 to 2012 describing DPH addiction. The literature search in reveals that the addictive potential of DPH can be regarded as proved, based on cases series, eight case reports, a pharmacological overview, one uncontrolled, and one randomized, placebo controlled study. In addition we report a case of an abstinent alcoholic patient treated in our department for DPH-dependency.

Conclusion: Especially when treating patients with a history of addiction, physicians should consider and check the possibility of a DPH dependency.

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