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Drug Res (Stuttg) 2013; 63(01): 46-51
DOI: 10.1055/s-0032-1333229
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis of 2,4-dihydroxychalcone Derivatives as Potential Antidepressant Effect

L.-P. Guan
1   Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan, China
,
D.-H. Zhao
2   Jilin Medical College, Jilin City, Jilin, China
,
Y. Chang
1   Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan, China
3   College of Pharmacy, Yanbian University, Yanji, Jilin, China
,
Z.-S. Wen
1   Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan, China
,
L.-M. Tang
1   Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan, China
,
F.-F. Huang
1   Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan, China
› Author Affiliations
Further Information

Publication History

received 28 September 2012

accepted 26 November 2012

Publication Date:
24 January 2013 (online)

Also available at
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Abstract

In this study, twelve 2,4-dihydroxychalcone derivatives were synthesized and evaluated for antidepressant activities using the forced swimming test (FST). The pharmacological test showed that 6 compounds significantly reduced the immobility times in the FST at a dose of 10 mg/kg, indicative of antidepressant activity. Among the derivatives, compounds designated 3d and 3 h exhibited the best antidepressant activity, with reduced immobility time by 32.05% and 34.33%, respectively. In the 5-hydroxytryptophan-induced head-twitch test and yohimbine-induced mortality test, compounds 3d and 3 h increased head-twitch and increased the mortality rate. The mechanisms of the antidepressant effects of compounds 3d and 3 h may be related with the 5-HTP and NE nervous system.

Key words

2,4-dihydroxychalcone derivatives - synthesis - antidepressant activity - 5-Hydroxytryptophan - yohimbine
 

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