Abstract
In this study, twelve 2,4-dihydroxychalcone derivatives were synthesized and evaluated
for antidepressant activities using the forced swimming test (FST). The pharmacological
test showed that 6 compounds significantly reduced the immobility times in the FST
at a dose of 10 mg/kg, indicative of antidepressant activity. Among the derivatives,
compounds designated 3d and 3 h exhibited the best antidepressant activity, with reduced
immobility time by 32.05% and 34.33%, respectively. In the 5-hydroxytryptophan-induced
head-twitch test and yohimbine-induced mortality test, compounds 3d and 3 h increased
head-twitch and increased the mortality rate. The mechanisms of the antidepressant
effects of compounds 3d and 3 h may be related with the 5-HTP and NE nervous system.
Key words
2,4-dihydroxychalcone derivatives - synthesis - antidepressant activity - 5-Hydroxytryptophan
- yohimbine