Drug Res (Stuttg) 2013; 63(03): 121-128
DOI: 10.1055/s-0032-1333275
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Activities of some Novel Benzhydrylpiperazine Derivatives

E. E. Gurdal
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey
M. Yarim
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey
I. Durmaz
2   Department of Molecular Biology and Genetics, BilGen, Genetics and Biotechnology Research Center, Faculty of Science, Bilkent University, Ankara, Turkey
R. Cetin-Atalay
2   Department of Molecular Biology and Genetics, BilGen, Genetics and Biotechnology Research Center, Faculty of Science, Bilkent University, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

received 27 November 2012

accepted 20 December 2012

Publication Date:
11 February 2013 (online)


This study presents the synthesis of nineteen 1-(substitutedbenzoyl)-4-benzhydrylpiperazine and 1-[(substitutedphenyl)sulfonyl]-4-benzhydrylpiperazine derivatives. In vitro cytotoxic activities of the compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Among the test compounds, benzamide derivatives had high cytotoxic activity whereas sulfonamide derivatives showed variable 50% growth inhibition (GI50).

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