Journal Club AINS 2012; 1(2): 77-79
DOI: 10.1055/s-0033-1333818
Journal Club
© Georg Thieme Verlag Stuttgart · New York

Vasopressin und Terlipressin beim vasodilatatorischen Schock

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Publication History

Publication Date:
14 January 2013 (online)

Eine wichtige Komponente der Therapie des vasodilatatorischen Schockgeschehens im Rahmen der Intensivmedizin ist der Einsatz von Katecholaminen. Bei prolongierter Anwendung kommt es jedoch zur Wirkungsverminderung durch Abnahme der Rezeptorzahl („Down-Regulation“) und Verminderung der Rezeptorsensibilität (Desensibilisierung). Die Möglichkeit, diesem Effekt durch zusätzliche Gabe von Vasopressin und dessen Analogon Terlipressin entgegenzuwirken, haben Serpa Neto und Kollegen im Rahmen einer Metaanalyse untersucht.

 
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