Subscribe to RSS
DOI: 10.1055/s-0033-1334460
Pregnancy and Perinatal Outcomes Associated with Acinetobacter baumannii Infection
Publication History
25 July 2012
27 July 2012
Publication Date:
07 February 2013 (online)
Abstract
Objective To determine perinatal and pregnancy outcomes of Acinetobacter baumannii infection using clinicopathologic material from pregnant women, neonates, and perinatal postmortem examinations with positive cultures.
Study Design This is a retrospective record review with placental and postmortem examination.
Results During a 5-year period, 40 positive cultures were found. Three pregnancies with positive cultures close in the peripartum period were all associated with adverse outcomes including spontaneous abortion, preterm labor, and one full-term birth with histological chorioamnionitis. Two positive cultures were found in preterm neonates in the neonatal intensive care unit. Two of three cases of perinatal death grew pure cultures from blood and/or fetal tissue with placental or fetal examination demonstrating evidence of infection/inflammation with fetal inflammatory response.
Conclusion This is the first case series report of A. baumannii-positive cultures in maternal, fetal, and neonatal specimen, with histopathologic evidence of infection. The results suggest a significant role of A. baumannii infection in adverse pregnancy and perinatal outcomes.
-
References
- 1 Neonakis IK, Spandidos DA, Petinaki E. Confronting multidrug-resistant Acinetobacter baumannii: a review. Int J Antimicrob Agents 2011; 37: 102-109
- 2 Falagas ME, Bliziotis IA, Siempos II. Attributable mortality of Acinetobacter baumannii infections in critically ill patients: a systematic review of matched cohort and case-control studies. Crit Care 2006; 10: R48
- 3 Gordon NC, Wareham DW. Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance. Int J Antimicrob Agents 2010; 35: 219-226
- 4 McGrath EJ, Chopra T, Abdel-Haq N , et al. An outbreak of carbapenem-resistant Acinetobacter baumannii infection in a neonatal intensive care unit: investigation and control. Infect Control Hosp Epidemiol 2011; 32: 34-41
- 5 Simmonds A, Munoz J, Aguero-Rosenfeld M , et al. Outbreak of Acinetobacter infection in extremely low birth weight neonates. Pediatr Infect Dis J 2009; 28: 210-214
- 6 Aivazova V, Kainer F, Friese K, Mylonas I. Acinetobacter baumannii infection during pregnancy and puerperium. Arch Gynecol Obstet 2010; 281: 171-174
- 7 Pinar H, Koch MA, Hawkins H , et al. The Stillbirth Collaborative Research Network Postmortem Examination Protocol. Am J Perinatol 2012; 29: 187-202
- 8 Pinar H, Koch MA, Hawkins H , et al. The Stillbirth Collaborative Research Network (SCRN) placental and umbilical cord examination protocol. Am J Perinatol 2011; 28: 781-792
- 9 Wareham DW, Bean DC, Khanna P , et al. Bloodstream infection due to Acinetobacter spp: epidemiology, risk factors and impact of multi-drug resistance. Eur J Clin Microbiol Infect Dis 2008; 27: 607-612
- 10 Wisplinghoff H, Edmond MB, Pfaller MA, Jones RN, Wenzel RP, Seifert H. Nosocomial bloodstream infections caused by Acinetobacter species in United States hospitals: clinical features, molecular epidemiology, and antimicrobial susceptibility. Clin Infect Dis 2000; 31: 690-697
- 11 Nagata K, Mino H, Yoshida S. [Usefulness and limit of Gram staining smear examination]. Rinsho Byori 2010; 58: 490-497 (Japanese)