Enantioselective Functionalization of Terminal Alkynes by Gold Catalysis

Asmaa Kamal Mourad; Constantin Czekelius

doi:10.1055/s-0033-1338841

Synlett, Table of Contents

Synlett 2013; 24(12): 1459-1463
DOI: 10.1055/s-0033-1338841

synpacts

Enantioselective Functionalization of Terminal Alkynes by Gold Catalysis

Authors

Asmaa Kamal Mourad

^aInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany Fax: +49(30)83853625 Email: cczekeli@chemie.fu-berlin.de

^bFayoum University, University Zone, Fayoum, 63514, Egypt
Constantin Czekelius*

^aInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany Fax: +49(30)83853625 Email: cczekeli@chemie.fu-berlin.de

Abstract

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Abstract

The enantioselective functionalization of alkynes is still a challenge in the field of gold catalysis. This article describes recent progress in the application of gold complexes with optically active ligands or counteranions for activation of alkynes towards nucleophiles, including the recently reported desymmetrization of terminal diynes.

Key words

alkynes - asymmetric catalysis - gold - isomerization - desymmetrization

Full Text

References

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