Synlett 2014; 25(13): 1901-1903
DOI: 10.1055/s-0033-1340187
letter
© Georg Thieme Verlag Stuttgart · New York

Reductive Passerini/Tsuji–Trost Strategy towards β,γ-Unsaturated Amides

Aurélie Dos Santos
DCSO-UMR 7652: CNRS-ENSTA-Ecole Polytechnique, Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 828 Bd des Maréchaux, 91128 Palaiseau, France   Email: laurent.elkaim@ensta-paristech.fr
,
Laurent El Kaïm*
DCSO-UMR 7652: CNRS-ENSTA-Ecole Polytechnique, Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 828 Bd des Maréchaux, 91128 Palaiseau, France   Email: laurent.elkaim@ensta-paristech.fr
› Author Affiliations
Further Information

Publication History

Received 17 April 2014

Accepted after revision: 30 April 2014

Publication Date:
03 June 2014 (online)


Abstract

The Passerini reaction of α,β-unsaturated aldehydes with formic acid followed by a reductive Tsuji–Trost reaction affords β,γ-unsaturated amides. The overall process may be viewed as a one-carbon homologation of unsaturated aldehydes into amides.

Supporting Information

 
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