Synthesis of Functionalized Octahydroindoles Related to Daphnyphyllum Alkaloids

Abstract

Functionalized octahydroindoles were synthesized from (±)-cyclohex-2-en-1-ol as potential intermediates for convergent syntheses of several alkaloids from plants of the Daphnyphyllum genus.

Key words

alkaloids - heterocycles - bicyclic compounds - natural products - hydrogenation - diastereoselectivity

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• 35 Crystallographic data for compounds 9, 11, 17, 27, 28, and 32 have been deposited with the accession numbers CCDC 968290, 968291, 968292, 968293, 968294, and 968295, respectively, and can be obtained free of charge from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; Fax: [phone]; E-mail: [e-mail]; Web site: www.ccdc.cam.ac.uk/conts/retrieving.html.