Studies of the New Reactivity of Chiral Acrylamides and Unprotected Pyrroles: Diastereoselective and Carbonyl Compatible 1,4-Addition

Abstract

A diversity of new functionalized cyclic and acyclic chiral pyrroloamides compounds were synthesized in good yields and diastereoselectivities in the case of cyclic pyrroloamides. This simple and robust process involves the creation of a C–C bond between unprotected pyrroles and cyclic or hindered chiral acrylamides.

Key words

acrylamides - Lewis acid - Friedel–Crafts reaction - pyrrole - lactams - peptides

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