AJP Rep 2013; 03(02): 087-090
DOI: 10.1055/s-0033-1343791
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Antiviral-Resistant Fulminant Herpes Hepatitis in Pregnancy

Christina A. Herrera
1   Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina
Kacey Y. Eichelberger
2   Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina
Nancy C. Chescheir
2   Division of Maternal Fetal Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina
› Author Affiliations
Further Information

Publication History

12 January 2013

26 February 2013

Publication Date:
21 May 2013 (online)


Fulminant herpes hepatitis with disseminated extrahepatic involvement in pregnancy is rare and carries a high mortality risk. Although acyclovir remains standard first-line therapy, effective management of acyclovir-resistant disseminated herpes simplex virus (HSV) in pregnancy remains elusive. We present a case of disseminated HSV resistant to both acyclovir and foscarnet, the first double-agent resistant case in pregnancy reported in the literature to date. In this case, therapeutic delivery was the ultimate treatment resulting in full recovery.

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