Adjunktive Therapieoptionen bei schweren bakteriellen Infektionen

• Literatur

• 1 Müller-Redetzky HC, Suttorp N, Witzenrath M. Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives. Cell Tissue Res 2014; 355: 657-673
• 2 Hippenstiel SM, Witzenrath B, Schmeck AC et al. Adrenomedullin reduces endothelial hyperpermeability. Circ Res 2002; 91: 618-625
• 3 Temmesfeld-Wollbrück B, Hocke AC, Suttorp N et al. Adrenomedullin and endothelial barrier function. Thromb Haemost 2007; 98: 944-951
• 4 Müller HC, Witzenrath M, Tschernig T et al. Adrenomedullin attenuates ventilator-induced lung injury in mice. Thorax 2010; 65: 1077-1084
• 5 Suttorp N, Weber U, Welsch T et al. Role of phosphodiesterases in the regulation of endothelial permeability in vitro. J Clin Invest 1993; 91: 1421-1428
• 6 Seybold J, Thomas D, Witzenrath M et al. Tumor necrosis factor-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability. Blood 2005; 105: 3569-3576
• 7 Suttorp N, Fuhrmann M, Tannert-Otto S et al. Pore forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells. J Exp Med 1993; 178: 337-341
• 8 Levy BD, Serhan CN. Resolution of acute inflammation in the lung. Annu Rev Physiol 2014; 76: 467-492
• 9 Herold S, Hoegner K, Vadász I et al. Inhaled granulocyte/macrophage colony-stimulating factor as treatment of pneumonia-associated acute respiratory distress syndrome. Am J Respir Crit Care Med 2014; 189: 609-611
• 10 Doehn JM, Fischer K, Reppe K. Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia. J Antimicrob Chemother 2013; 68: 2111-2117
• 11 Witzenrath M, Schmeck B, Doehn JM et al. Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia. Crit Care Med 2009; 37: 642-649