Klin Padiatr 2014; 226(01): 29-37
DOI: 10.1055/s-0033-1361104
Report
© Georg Thieme Verlag KG Stuttgart · New York

Behandlung der neonatalen Asphyxie unter besonderer Berücksichtigung der therapeutischen Hypothermie

Treatment of Neonatal Asphyxia with a Special Focus on Therapeutic Hypothermia
A. W. Flemmer
1   Neonatologie der Kinderklinik am Perinatalzentrum der Ludwig-Maximilians-Universität München
,
R. F. Maier
2   Klinik für Kinder- und Jugendmedizin Marburg, Universitätsklinikum Gießen und Marburg
,
H. Hummler
3   Sektion Neonatologie und Pädiatrische Intensivmedizin, Universitätsklinikum Ulm
› Author Affiliations
Further Information

Publication History

Publication Date:
16 January 2014 (online)

Zusammenfassung

Die Behandlung von Neugeborenen nach neonataler Asphyxie hat in den vergangenen Jahren eine Vielzahl von neuen Entwicklungen erfahren. Ein wesentlicher Meilenstein waren dabei die positiven Ergebnisse verschiedener Studien zur prophylaktischen Behandlung der hypoxisch-ischämischen Enzephalopathie mit Hilfe einer moderaten Kühlung des Kindes bzw. seines Kopfes. In dieser Arbeit wurde versucht, mit einer konsentierten Leitlinie eine Hilfestellung in der Therapieentscheidung für betroffene Kinder zu geben und so zu einer Homogenisierung der Behandlungsstrategien im deutschsprachigen Raum beizutragen.

Abstract

In recent years the treatment of newborns for neonatal asphyxia has experienced a lot of new developments. A major milestone were the positive results of various trials for prophylactic treatment of hypoxic-ischemic encephalopathy by moderate cooling of the child or of his head. With this paper we attempt to provide a consented guideline to aid in the treatment decision for affected newborns and thus achieve a more homogeneous treatment strategy throughout Germany.

 
  • Literatur

  • 1 American College of Obstetricians and Gynecologists (ACOG) . Neonatal encephalopathy and cerebral palsy: executive summary. Obstet Gynecol 2004; 103: 780-781
  • 2 Azzopardi DV, Strohm B, Edwards AD et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009; 361: 1349-1358
  • 3 Bhat MA, Shah ZA, Makhdoomi MS et al. Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. J Pediatr 2006; 149: 180-184
  • 4 Davis PG, Tan A, O’Donnell CPF et al. Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis. Lancet 2004; 364: 1329-1333
  • 5 Dawson JA, Kamlin COF, Vento M et al. Defining the reference range for oxygen saturation for infants after birth. Pediatrics 2010; 125: e1340-e1347
  • 6 de Vries LS, Jongmans MJ. Long-term outcome after neonatal hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 2010; 95: F220-F224
  • 7 Edwards AD, Brocklehurst P, Gunn AJ et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ 2010; 340: c363
  • 8 Eicher DJ, Wagner CL, Katikaneni LP et al. Moderate hypothermia in neonatal encephalopathy: efficacy outcomes. Pediatr Neurol 2005; 32: 11-17
  • 9 Evans DJ, Levene MI, Tsakmakis M. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. Cochrane Database Syst Rev 2007; CD001240
  • 10 Gluckman PD, Wyatt JS, Azzopardi D et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005; 365: 663-670
  • 11 Graham EM, Ruis KA, Hartman AL et al. A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol 2008; 199: 587-595
  • 12 Hafström M, Ehnberg S, Blad S et al. Developmental outcome at 6.5 years after acidosis in term newborns: a population-based study. Pediatrics 2012; 129: e1501-e1507
  • 13 Hallberg B, Grossmann K, Bartocci M et al. The prognostic value of early aEEG in asphyxiated infants undergoing systemic hypothermia treatment. Acta Paediatr 2010; 99: 531-536
  • 14 Jacobs S, Berg M, Hunt R et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2013; CD003311
  • 15 Jacobs SE, Morley CJ, Inder TE et al. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial. Arch Pediatr Adolesc Med 2011; 165: 692-700
  • 16 Lin ZL, Yu HM, Lin J et al. Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit. J Perinatol 2006; 26: 180-184
  • 17 Martinez-Biarge M, Diez-Sebastian J, Kapellou O et al. Predicting motor outcome and death in term hypoxic-ischemic encephalopathy. Neurology 2011; 76: 2055-2061
  • 18 Pappas A, Shankaran S, Laptook AR et al. Hypocarbia and adverse outcome in neonatal hypoxic-ischemic encephalopathy. J Pediatr 2011; 158: 752.e1-758.e1
  • 19 Perlman JM, Wyllie J, Kattwinkel J et al. Neonatal resuscitation. 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations 2010; e1319-e1344
  • 20 Rabi Y, Rabi D, Yee W. Room air resuscitation of the depressed newborn: a systematic review and meta-analysis. Resuscitation 2007; 72: 353-363
  • 21 Richmond S, Wyllie J. European Resuscitation Council Guidelines for Resuscitation 2010 Section 7. Resuscitation of babies at birth. Resuscitation 2010; 81: 1389-1399
  • 22 Rutherford M, Ramenghi LA, Edwards AD et al. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial. Lancet Neurol 2010; 9: 39-45
  • 23 Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 1976; 33: 696-705
  • 24 Shah PS. Hypothermia: a systematic review and meta-analysis of clinical trials. Semin Fetal Neonatal Med 2010; 15: 238-246
  • 25 Shah PS, Beyene J, To T et al. Postasphyxial hypoxic-ischemic encephalopathy in neonates: outcome prediction rule within 4 hours of birth. Arch Pediatr Adolesc Med 2006; 160: 729-736
  • 26 Shankaran S, Pappas A, McDonald SA et al. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med 2012; 366: 2085-2092
  • 27 Shankaran S, Laptook AR, Ehrenkranz RA et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005; 353: 1574-1584
  • 28 Simbruner G, Mittal RA, Rohlmann F et al. Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT. Pediatrics 2010; 126: e771-e778
  • 29 Tagin MA, Woolcott CG, Vincer MJ et al. Hypothermia for neonatal hypoxic ischemic encepha-lopathy: an updated systematic review and meta-analysis. Arch Pediatr Adolesc Med 2012; 166: 558-566
  • 30 Zhou W-H, Cheng G-Q, Shao X-M et al. Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China. J Pediatr 2010; 157: 367-372 372.e1–e3