Download PDF
Drug Res (Stuttg) 2015; 65(07): 344-346
DOI: 10.1055/s-0034-1372610
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Efficacy and Safety of Sufentanil and Pethidine in Spinal Anesthesia for Painless Labor

S. Salarian
1   Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
M. Fathi
1   Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
B. Farzanegan
1   Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
B. Bagheri
2   Department of Pharmacology, Semnan University of Medical Sciences, Semnan, Iran
› Author Affiliations
Further Information

Publication History

received 14 January 2014

accepted 24 March 2014

Publication Date:
29 April 2014 (online)

Also available at
    Permissions and Reprints

Abstract

Purpose:

Saddle spinal is a reliable method for control of pain during labor. This method has rapid onset and causes complete sensory block without significant influence on motor neurons.

Our goal was to compare the analgesic efficacy and side effects of pethidine and sufentanil via saddle spinal administration during labor.

Methods:

600 parturients requesting analgesia were randomly divided into 2 groups. First group was composed of 300 patients received 0.4 mg/kg pethidine and the second group was composed of 300 patients received 0.1 μg/kg sufentanil. Then, analgesia according to Visual Analogue Scale (VAS), itching, nausea, apnea and urinary retention were examined between 2 groups.

Results:

VAS=3 was noted in both groups. Equal rate of apnea was seen in both groups. Patients received pethidine showed significantly a higher rate of nausea compared with sufentanil group (P<0.0001). Pruritus was significantly higher in patients received sufantanil (P<0.0001).

Conclusions:

Our findings suggest that saddle spinal by pethidine or sufentanil causes a considerable analgesia for labor. Proper management of the untoward effects of this method may introduce it as a safe and low-cost method for painless labor.

Key words

analgesia - painless labor - pethidine - sufentanil - pruritus - nausea
 

  • References

  • 1 Wong CA. Advances in labor analgesia. Int J Women Health 2009; 1: 139-154
    PubMedGoogle Scholar
  • 2 Wall P, Melzack R. Wall and Melzack’s Text Book of Pain. 5th ed. Philadelphia: W.B. Saunders Company; 2006: 802-813
    Google Scholar
  • 3 Miller DR. Miller’s Anesthesia. 7thed. Elsevier; 2008: 1654-1660
    Google Scholar
  • 4 Goodman S, Smiley R, Negron M et al. Association of anesthetists of Great Britain and Ireland. Anaesthesia J 2011; 66: 191-212
    PubMedGoogle Scholar
  • 5 Deballi P, Breen TW. Intrathecal opioids for combined spinal-epidural analgesia during labor. CNS Drugs 2003; 17: 889-904
    CrossrefPubMedGoogle Scholar
  • 6 Cohen S, Amar D, Pantuck CK. Epidural analgesia for labor and delivery: Fentanyl or sufentanil?. Can J Anesth 1996; 46: 341-346
    PubMedGoogle Scholar
  • 7 Pandya ST. Labor analgesia: Recent advances. Indian J Anes 2010; s4: 400-408
    PubMedGoogle Scholar
  • 8 Volikas I, Male D. A comparison of pethidine and remifentanil patient-controlled analgesia in labour. Int J Obstet Anesth 2001; 10: 86-90
    CrossrefPubMedGoogle Scholar
  • 9 Akkamahadevi P, Srinivas HT, Siddesh A et al. Comparison of efficacy of sufentanil and fentanyl with low-concentration bupivacaine for combined spinal epidural labor analgesia. Indian J Anes 2012; 365-3697
    PubMedGoogle Scholar
  • 10 Evron S, Glezerman M, Sadan O et al. Remifentanil: A novel systemic analgesic for labor pain. Anesth Analg 2005; 100: 233-238
    CrossrefPubMedGoogle Scholar
  • 11 White JL, Durieux ME. Clinical pharmacology of local anesthetics. Anesthesiol Clin North Am 2005; 23: 73
    CrossrefPubMedGoogle Scholar
  • 12 Smith MT. Differences between and combinations of opioids re-visited. Curr Opin Anaesthesiol 2008; 21: 596
    CrossrefPubMedGoogle Scholar
  • 13 Bernards CM. Recent insights into the pharmacokinetics of spinal opioids and the relevance to opioid selection. Curr Opin Anaesthesiol 2004; 17: 441-447
    CrossrefPubMedGoogle Scholar
  • 14 Sudharma RJ, Birnbach D. Progress in analgesia for labor: focus on neuraxial blocks. Int J Women Health 2009; 1: 31-34
    PubMedGoogle Scholar
  • 15 Blair JM, Dobson GT, Hill DA et al. Patient controlled analgesia for labor: a comparison of remifentanil with pethidine. Anaesthesia 2005; 60: 22-27
    CrossrefPubMedGoogle Scholar