Synlett 2015; 26(16): 2325-2326
DOI: 10.1055/s-0034-1381172
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© Georg Thieme Verlag Stuttgart · New York

Indole, a Privileged Structural Core Motif

Isaac Giménez Sonsona
Laboratorio de Organocatálisis Asimétrica, Departamento de Química Orgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza, C/ Pedro Cerbuna 12, E-50009 Zaragoza, Spain   Email: sonsona@unizar.es
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Publication History

Publication Date:
14 August 2015 (online)

Introduction

Indole (1), denominated by some authors as The Lord of the Rings of heterocyclic compounds[1] due to its importance in fields like chemistry, biology, and medicine,[2] represents the structural core of many natural and non-natural products with a wide range of biological properties, including antiviral[3] and anticancer[4] activities. An example of this spectrum of utilities is Arbidol (2), which is administered as a drug in Russia and China against influenza and other respiratory viral infections.[5] Recent examples of other applications of indole-containing compounds are their potential use in SPECT imaging or detecting Aβ plaques in Alzheimer’s disease, as compound 3,[6] or their use as ligands in the synthesis of organometallic complexes with optoelectronic properties and with potential use in the construction of light-emitting devices.[7]

Zoom Image
Figure 1 Indole-based target compounds
 
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