Endoscopy 2015; 47(06): 508-516
DOI: 10.1055/s-0034-1391304
Original article
© Georg Thieme Verlag KG Stuttgart · New York

Self-expandable metallic stents vs. plastic stents for endoscopic biliary drainage in hepatocellular carcinoma

Kwang Hyun Chung
1   Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
,
Sang Hyub Lee
1   Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
,
Jin Myung Park
1   Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
3   Department of Internal Medicine, Kangwon National University School of Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea.
,
Jae Min Lee
1   Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
4   Department of Internal Medicine, Myongji Hospital, Goyang, Republic of Korea
,
Dong-Won Ahn
2   Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea
,
Ji Kon Ryu
1   Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
,
Yong-Tae Kim
1   Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
› Author Affiliations
Further Information

Publication History

submitted 23 June 2014

accepted after revision 19 November 2014

Publication Date:
15 January 2015 (online)

Background and study aims: The patency of self-expandable metallic stents (SEMS) is known to be better than plastic stents in the palliation of malignant biliary obstruction. However, data are scarce for obstructive jaundice caused by hepatocellular carcinoma (HCC). This study aimed to compare SEMSs and plastic stents for the palliation of obstructive jaundice in unresectable HCC.

Patients and methods: A total of 96 patients who underwent endoscopic retrograde biliary drainage with SEMSs or plastic stents were included in this retrospective analysis. The rate of successful biliary drainage, adverse events, stent patency duration, and patient survival were compared between the SEMS (n = 36) and plastic stent (n = 60) groups.

Results: The rate of successful biliary drainage was similar between the SEMS and plastic stent groups (25/36 [69.4 %] vs. 39/60 [65.0 %]; P = 0.655). Adverse events occurred in 6 patients (16.7 %) in the SEMS group and 13 patients (21.7 %) in the plastic stent group (P = 0.552). The median patency duration was also similar between the two groups (60 vs. 68 days; P = 0.396). The median patient survival was longer in the plastic stent group than in the SEMS group (123 vs. 48 days; P = 0.005).

Conclusions: SEMSs were not superior to plastic stents for the palliation of malignant biliary obstruction in HCC with regard to successful drainage, stent patency, and adverse events. Patient survival was better in the plastic stent group. Given the lower cost, plastic stents could be a favorable option for malignant biliary obstruction caused by HCC.

 
  • References

  • 1 Kew MC, Geddes EW. Hepatocellular carcinoma in rural southern African blacks. Medicine 1982; 61: 98-108
  • 2 Ihde DC, Sherlock P, Winawer SJ et al. Clinical manifestations of hepatoma. A review of 6 years’ experience at a cancer hospital. Am J Med 1974; 56: 83-91
  • 3 Lau WY, Leow CK, Leung KL et al. Cholangiographic features in the diagnosis and management of obstructive icteric type hepatocellular carcinoma. HPB Surg 2000; 11: 299-306
  • 4 Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7: 462-503
  • 5 Becker FF. Hepatoma – nature’s model tumor. A review. Am J Pathol 1974; 74: 179-210
  • 6 Kew MC, Paterson AC. Unusual clinical presentations of hepatocellular carcinoma. Trop Gastroenterol 1985; 6: 10-22
  • 7 Qin LX, Tang ZY. Hepatocellular carcinoma with obstructive jaundice: diagnosis, treatment and prognosis. World J Gastroenterol 2003; 9: 385-391
  • 8 Cho HC, Lee JK, Lee KH et al. Are endoscopic or percutaneous biliary drainage effective for obstructive jaundice caused by hepatocellular carcinoma?. Eur J Gastroenterol Hepatol 2011; 23: 224-231
  • 9 Garcea G, Ong SL, Dennison AR et al. Palliation of malignant obstructive jaundice. Dig Dis Sci 2009; 54: 1184-1198
  • 10 Minami Y, Kudo M. Hepatocellular carcinoma with obstructive jaundice: endoscopic and percutaneous biliary drainage. Dig Dis 2012; 30: 592-597
  • 11 Choi J, Ryu JK, Lee SH et al. Biliary drainage for obstructive jaundice caused by unresectable hepatocellular carcinoma: the endoscopic versus percutaneous approach. Hepatobiliary Pancreatic Dis Int 2012; 11: 636-642
  • 12 Davids PH, Groen AK, Rauws EA et al. Randomised trial of self-expanding metal stents versus polyethylene stents for distal malignant biliary obstruction. Lancet 1992; 340: 1488-1492
  • 13 Knyrim K, Wagner HJ, Pausch J et al. A prospective, randomized, controlled trial of metal stents for malignant obstruction of the common bile duct. Endoscopy 1993; 25: 207-212
  • 14 Prat F, Chapat O, Ducot B et al. A randomized trial of endoscopic drainage methods for inoperable malignant strictures of the common bile duct. Gastrointest Endosc 1998; 47: 1-7
  • 15 Kaassis M, Boyer J, Dumas R et al. Plastic or metal stents for malignant stricture of the common bile duct? Results of a randomized prospective study. Gastrointest Endosc 2003; 57: 178-182
  • 16 Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 2010; 17: 1471-1474
  • 17 Lau WY. Management of hepatocellular carcinoma. J Royal Coll Surg Edinburgh 2002; 47: 389-399
  • 18 Hong HP, Kim SK, Seo TS. Percutaneous metallic stents in patients with obstructive jaundice due to hepatocellular carcinoma. J Vasc Interv Radiol 2008; 19: 748-754
  • 19 Banks PA, Freeman ML. Practice Parameters Committee of the American College of G. Practice guidelines in acute pancreatitis. Am J Gastroenterol 2006; 101: 2379-2400
  • 20 Kapral C, Duller C, Wewalka F et al. Case volume and outcome of endoscopic retrograde cholangiopancreatography: results of a nationwide Austrian benchmarking project. Endoscopy 2008; 40: 625-630
  • 21 Cote GA, Sherman S. Advances in pancreatobiliary endoscopy. Curr Opin Gastroenterol 2010; 26: 429-435
  • 22 Soderlund C, Linder S. Covered metal versus plastic stents for malignant common bile duct stenosis: a prospective, randomized, controlled trial. Gastrointest Endosc 2006; 63: 986-995
  • 23 Yoon WJ, Ryu JK, Yang KY et al. A comparison of metal and plastic stents for the relief of jaundice in unresectable malignant biliary obstruction in Korea: an emphasis on cost-effectiveness in a country with a low ERCP cost. Gastrointest Endosc 2009; 70: 284-289
  • 24 Levy MJ, Baron TH, Gostout CJ et al. Palliation of malignant extrahepatic biliary obstruction with plastic versus expandable metal stents: an evidence-based approach. Clin Gastroenterol Hepatol 2004; 2: 273-285
  • 25 Choi J, Shim JH, Park do H et al. Clinical usefulness of endoscopic palliation in patients with biliary obstruction caused by hepatocellular carcinoma. Digestion 2013; 88: 87-94
  • 26 Cabibbo G, Enea M, Attanasio M et al. A meta-analysis of survival rates of untreated patients in randomized clinical trials of hepatocellular carcinoma. Hepatology 2010; 51: 1274-1283
  • 27 Shiina S, Teratani T, Obi S et al. A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma. Gastroenterology 2005; 129: 122-130
  • 28 Lin SM, Lin CJ, Lin CC et al. Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma < or = 4 cm. Gastroenterology 2004; 127: 1714-1723
  • 29 Livraghi T, Giorgio A, Marin G et al. Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection. Radiology 1995; 197: 101-108
  • 30 Bruix J, Sala M, Llovet JM. Chemoembolization for hepatocellular carcinoma. Gastroenterology 2004; 127: 179-188