Semin Reprod Med 2015; 33(02): 065-076
DOI: 10.1055/s-0035-1545364
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Prognostic Factors for IVF Success: Diagnostic Testing and Evidence-Based Interventions

Athanasios Papathanasiou
1  Bourn-Hall Clinic, Wymondham, Norwich, United Kingdom
Siladitya Bhattacharya
2  Aberdeen University, Foresterhill, Aberdeen, United Kingdom
› Author Affiliations
Further Information

Publication History

Publication Date:
03 March 2015 (online)


Numerous tests and interventions have been proposed for optimizing performance in preparation for in vitro fertilization (IVF) treatment. We critically appraised the available evidence underpinning some of the popular investigations and treatments, including the role of hysteroscopy, laparoscopy, ovarian reserve tests, sperm function tests, as well as the role of lifestyle modifications or surgery for endometriosis, fibroids, and endometrial polyps. We also reviewed the evidence behind novel techniques, such as the use of endometrial injury before IVF. Only a few of the aforementioned modalities are justified based on the available research evidence. Other factors may affect the uptake of a test or intervention before IVF, namely the complexity of the proposed modality, its potential for harm, and its cost-effectiveness.