Clin Colon Rectal Surg 2015; 28(02): 079-086
DOI: 10.1055/s-0035-1547335
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Parasitic Colitis

Elizabeth M. Hechenbleikner
1   Department of Surgery, MedStar Georgetown University Hospital, Washington, District of Columbia
,
Jennifer A. McQuade
2   Department of Colorectal Surgery, Virginia Hospital Center, Arlington, Virginia
› Author Affiliations
Further Information

Publication History

Publication Date:
25 May 2015 (online)

Abstract

Over one billion people worldwide harbor intestinal parasites. Parasitic intestinal infections have a predilection for developing countries due to overcrowding and poor sanitation but are also found in developed nations, such as the United States, particularly in immigrants or in the setting of sporadic outbreaks. Although the majority of people are asymptomatically colonized with parasites, the clinical presentation can range from mild abdominal discomfort or diarrhea to serious complications, such as perforation or bleeding. Protozoa and helminths (worms) are the two major classes of intestinal parasites. Protozoal intestinal infections include cryptosporidiosis, cystoisosporiasis, cyclosporiasis, balantidiasis, giardiasis, amebiasis, and Chagas disease, while helminth infections include ascariasis, trichuriasis, strongyloidiasis, enterobiasis, and schistosomiasis. Intestinal parasites are predominantly small intestine pathogens but the large intestine is also frequently involved. This article highlights important aspects of parasitic infections of the colon including epidemiology, transmission, symptoms, and diagnostic methods as well as appropriate medical and surgical treatment.

 
  • References

  • 1 Huston CD. Parasite and host contributions to the pathogenesis of amebic colitis. Trends Parasitol 2004; 20 (1) 23-26
  • 2 Crompton DW, Savioli L. Intestinal parasitic infections and urbanization. Bull World Health Organ 1993; 71 (1) 1-7
  • 3 Harhay MO, Horton J, Olliaro PL. Epidemiology and control of human gastrointestinal parasites in children. Expert Rev Anti Infect Ther 2010; 8 (2) 219-234
  • 4 Polage CR, Stoddard GJ, Rolfs RT, Petti CA. Physician use of parasite tests in the United States from 1997 to 2006 and in a Utah Cryptosporidium outbreak in 2007. J Clin Microbiol 2011; 49 (2) 591-596
  • 5 Castro GA. Helminths: Structure, Classification, Growth, and Development. In: Baron S, , ed. Medical Microbiology. 4th ed. Galveston, TX: University of Texas Medical Branch, Department of Microbiology; 1996: 1023-1033
  • 6 Kucik CJ, Martin GL, Sortor BV. Common intestinal parasites. Am Fam Physician 2004; 69 (5) 1161-1168
  • 7 Kirchhoff LV. American Trypanosomiasis (Chagas' Disease). In: Guerrant RL, Walker DH, Weller PF, , eds. Tropical Infectious Diseases: Principles, Pathogens, & Practice. Volume 1. Philadelphia, PA: Churchill Livingstone; 1999: 785-796
  • 8 Ortega YR, Sanchez R. Update on Cyclospora cayetanensis, a food-borne and waterborne parasite. Clin Microbiol Rev 2010; 23 (1) 218-234
  • 9 Pierce KK, Kirkpatrick BD. Update on human infections caused by intestinal protozoa. Curr Opin Gastroenterol 2009; 25 (1) 12-17
  • 10 Derouin F, Lagrange-Xelot M. Treatment of parasitic diarrhea in HIV-infected patients. Expert Rev Anti Infect Ther 2008; 6 (3) 337-349
  • 11 Fayer R, Ungar BL. Cryptosporidium spp. and cryptosporidiosis. Microbiol Rev 1986; 50 (4) 458-483
  • 12 Legua P, Seas C. Cystoisospora and cyclospora. Curr Opin Infect Dis 2013; 26 (5) 479-483
  • 13 Rossignol JF, Ayoub A, Ayers MS. Treatment of diarrhea caused by Cryptosporidium parvum: a prospective randomized, double-blind, placebo-controlled study of Nitazoxanide. J Infect Dis 2001; 184 (1) 103-106
  • 14 Anonymous. Drugs for parasitic infections. Med Lett Drugs Ther 1969; 11 (6, Suppl): 21-28 . Available at: http://gorgas.dom.uab.edu/.../03_Parasites/RxParasitesMedicalLetter2013.pdf Accessed May 15, 2014
  • 15 Blanshard C, Jackson AM, Shanson DC, Francis N, Gazzard BG. Cryptosporidiosis in HIV-seropositive patients. Q J Med 1992; 85 (307-308) 813-823
  • 16 Schuster FL, Ramirez-Avila L. Current world status of Balantidium coli. Clin Microbiol Rev 2008; 21 (4) 626-638
  • 17 Agapov M. Balantidiasis in a patient with suspected Crohn's disease. Endoscopy 2006; 38 (6) 655
  • 18 Anargyrou K, Petrikkos GL, Suller MTE , et al. Pulmonary Balantidium coli infection in a leukemic patient. Am J Hematol 2003; 73 (3) 180-183
  • 19 Yoder JS, Harral C, Beach MJ ; Centers for Disease Control and Prevention (CDC). Giardiasis surveillance - United States, 2006-2008. MMWR Surveill Summ 2010; 59 (6) 15-25
  • 20 Thompson RC. Giardiasis as a re-emerging infectious disease and its zoonotic potential. Int J Parasitol 2000; 30 (12-13) 1259-1267
  • 21 Hellard ME, Sinclair MI, Hogg GG, Fairley CK. Prevalence of enteric pathogens among community based asymptomatic individuals. J Gastroenterol Hepatol 2000; 15 (3) 290-293
  • 22 Ajjampur SSR, Koshy B, Venkataramani M , et al. Effect of cryptosporidial and giardial diarrhoea on social maturity, intelligence and physical growth in children in a semi-urban slum in south India. Ann Trop Paediatr 2011; 31 (3) 205-212
  • 23 Petri WA, Singh U, Ravdin JI. Enteric Amebiasis. In: Guerrant RL, Walker DH, Weller PF, , eds. Tropical Infectious Diseases: Principles, Pathogens, & Practice. Volume 1. Philadelphia, PA: Churchill Livingstone; 1999: 685-702
  • 24 Otan E, Akbulut S, Kayaalp C. Amebic acute appendicitis: systematic review of 174 cases. World J Surg 2013; 37 (9) 2061-2073
  • 25 Ishida H, Inokuma S, Murata N, Hashimoto D, Satoh K, Ohta S. Fulminant amoebic colitis with perforation successfully treated by staged surgery: a case report. J Gastroenterol 2003; 38 (1) 92-96
  • 26 Wruble LD, Duckworth JK, Duke DD, Rothschild JA. Toxic dilatation of the colon in a case of amebiasis. N Engl J Med 1966; 275 (17) 926-928
  • 27 Alavi KA. Amebiasis. Clin Colon Rectal Surg 2007; 20 (1) 33-37
  • 28 Singh A, Houpt E, Petri WA. Rapid diagnosis of intestinal parasitic protozoa, with a focus on Entamoeba histolytica. Interdiscip Perspect Infect Dis 2009; 2009: 547090
  • 29 Krogstad DJ, Spencer Jr HC, Healy GR, Gleason NN, Sexton DJ, Herron CA. Amebiasis: epidemiologic studies in the United States, 1971-1974. Ann Intern Med 1978; 88 (1) 89-97
  • 30 Bern C, Kjos S, Yabsley MJ, Montgomery SP. Trypanosoma cruzi and Chagas' Disease in the United States. Clin Microbiol Rev 2011; 24 (4) 655-681
  • 31 Montgomery SP, Starr MC, Cantey PT, Edwards MS, Meymandi SK. Neglected parasitic infections in the United States: Chagas disease. Am J Trop Med Hyg 2014; 90 (5) 814-818
  • 32 Pinazo MJ, Cañas E, Elizalde JI , et al. Diagnosis, management and treatment of chronic Chagas' gastrointestinal disease in areas where Trypanosoma cruzi infection is not endemic. Gastroenterol Hepatol 2010; 33 (3) 191-200
  • 33 Netinho JG, Cunrath GS, Ronchi LS. Rectosigmoidectomy with ileal loop interposition: a new surgical method for the treatment of chagasic megacolon. Dis Colon Rectum 2002; 45 (10) 1387-1392
  • 34 Teixeira FV, Netinho JG. Surgical treatment of chagasic megacolon: Duhamel-Haddad procedure is also a good option. Dis Colon Rectum 2003; 46 (11) 1576-, author reply 1577–1578
  • 35 Hotez PJ, Bundy DAP, Beegle K , et al. Helminth Infections: Soil-transmitted Helminth Infections and Schistosomiasis. In: Jamison DT, Breman JG, Measham AR, , et al., eds. Disease Control Priorities in Developing Countries. 2nd ed. Washington, DC: The World Bank and Oxford University Press; 2006: 467-482
  • 36 Bethony J, Brooker S, Albonico M , et al. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 2006; 367 (9521) 1521-1532
  • 37 Wang X, Zhang L, Luo R , et al. Soil-transmitted helminth infections and correlated risk factors in preschool and school-aged children in rural Southwest China. PLoS ONE 2012; 7 (9) e45939
  • 38 Tietze PE, Tietze PH. The roundworm, Ascaris lumbricoides. Prim Care 1991; 18 (1) 25-41
  • 39 Khuroo MS. Ascariasis. Gastroenterol Clin North Am 1996; 25 (3) 553-577
  • 40 Lindo JF, Dubon JM, Ager AL , et al. Intestinal parasitic infections in human immunodeficiency virus (HIV)-positive and HIV-negative individuals in San Pedro Sula, Honduras. Am J Trop Med Hyg 1998; 58 (4) 431-435
  • 41 Elyse S, Barry M. Ascariasis. In: Guerrant RL, Walker DH, Weller PF, , eds. Tropical Infectious Diseases: Principles, Pathogens, & Practice. Volume 2. Philadelphia, PA: Churchill Livingstone; 1999: 959-965
  • 42 Villamizar E, Méndez M, Bonilla E, Varon H, de Onatra S. Ascaris lumbricoides infestation as a cause of intestinal obstruction in children: experience with 87 cases. J Pediatr Surg 1996; 31 (1) 201-204 , discussion 204–205
  • 43 Hefny AF, Saadeldin YA, Abu-Zidan FM. Management algorithm for intestinal obstruction due to ascariasis: a case report and review of the literature. Ulus Travma Acil Cerrahi Derg 2009; 15 (3) 301-305
  • 44 Deeg KH. Sonographic diagnosis of biliary ascariasis. Eur J Pediatr 1990; 150 (2) 95-96
  • 45 Cooper ES. Trichuriasis. In: Guerrant RL, Walker DH, Weller PF, , eds. Tropical Infectious Diseases: Principles, Pathogens, & Practice. Volume 2. Philadelphia, PA: Churchill Livingstone; 1999: 955-958
  • 46 Soriano LR, Del Mundo F, Naguit-Sim L. Rectal prolapse in children with trichuriasis. J Philipp Med Assoc 1966; 42 (12) 843-848
  • 47 Wang DD, Wang XL, Wang XL, Wang S, An CL. Trichuriasis diagnosed by colonoscopy: case report and review of the literature spanning 22 years in mainland China. Int J Infect Dis 2013; 17 (11) e1073-e1075
  • 48 Genta RM. Strongyloidiasis. In: Guerrant RL, Walker DH, Weller PF, , eds. Tropical Infectious Diseases: Principles, Pathogens, & Practice. Volume 2. Philadelphia, PA: Churchill Livingstone; 1999: 975-984
  • 49 Starr MC, Montgomery SP. Soil-transmitted Helminthiasis in the United States: a systematic review—1940-2010. Am J Trop Med Hyg 2011; 85 (4) 680-684
  • 50 Qu Z, Kundu UR, Abadeer RA, Wanger A. Strongyloides colitis is a lethal mimic of ulcerative colitis: the key morphologic differential diagnosis. Hum Pathol 2009; 40 (4) 572-577
  • 51 Al Samman M, Haque S, Long JD. Strongyloidiasis colitis: a case report and review of the literature. J Clin Gastroenterol 1999; 28 (1) 77-80
  • 52 Lohiya GS, Tan-Figueroa L, Crinella FM, Lohiya S. Epidemiology and control of enterobiasis in a developmental center. West J Med 2000; 172 (5) 305-308
  • 53 Alum A, Rubino JR, Ijaz MK. The global war against intestinal parasites—should we use a holistic approach?. Int J Infect Dis 2010; 14 (9) e732-e738
  • 54 Cook GC. Enterobius vermicularis infection. Gut 1994; 35 (9) 1159-1162
  • 55 Zakaria OM, Zakaria HM, Daoud MY , et al. Parasitic infestation in pediatric and adolescent appendicitis: a local experience. Oman Med J 2013; 28 (2) 92-96
  • 56 Liu LX. Enterobiasis. In: Guerrant RL, Walker DH, Weller PF, , eds. Tropical Infectious Diseases: Principles, Pathogens, & Practice. Volume 2. Philadelphia, PA: Churchill Livingstone; 1999: 949-953
  • 57 Ross AGP, Bartley PB, Sleigh AC , et al. Schistosomiasis. N Engl J Med 2002; 346 (16) 1212-1220
  • 58 King CH, Mahmoud AA. Schistosomiasis. In: Guerrant RL, Walker DG, Weller PF, , eds. Tropical Infectious Diseases: Principles, Pathogens, & Practice. Volume 2. Philadelphia, PA: Churchill Livingstone; 1999: 1031-1038
  • 59 Cao J, Liu W-J, Xu X-Y, Zou X-P. Endoscopic findings and clinicopathologic characteristics of colonic schistosomiasis: a report of 46 cases. World J Gastroenterol 2010; 16 (6) 723-727
  • 60 WHO Expert Committee on the Control of Schistosomiasis. Public health impact of schistosomiasis: disease and mortality. Bull World Health Organ 1993; 71 (6) 657-662
  • 61 Corachan M. Schistosomiasis and international travel. Clin Infect Dis 2002; 35 (4) 446-450