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Int Arch Otorhinolaryngol 2015; 19(03): 196-199
DOI: 10.1055/s-0035-1547521
Original Research
Thieme Publicações Ltda Rio de Janeiro, Brazil

Rhinosinusal Polyposis and Inverted Papilloma: A Morphometric Comparative Study

Gabriel Costa Andrade
1   Faculadade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil
,
Luciana Harumi Fujise
1   Faculadade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil
,
Atílio Maximino Fernandes
1   Faculadade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil
,
Reinaldo Azoubel
1   Faculadade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil
› Author Affiliations
Further Information

Publication History

08 September 2014

21 January 2015

Publication Date:
12 March 2015 (online)

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Abstract

Introduction Nasal obstruction is one of the main rhinologic complaints, and two diseases must be investigated as differential diagnosis: rhinosinusal polyposis and inverted papilloma. Using traditional methods, the differential diagnosis between these diseases may be difficult. The morphometric study may be a useful tool for differential diagnosis and to define prognosis.

Objective Calculate the morphometric values of rhinosinusal polyposis and inverted papilloma and compare the average of variables obtained between the groups.

Methods The nasal mucus of 10 patients who had surgery in the Department of Otorhinolaryngology and Surgery of Head and Neck was studied; 5 had rhinosinusal polyposis and 5 had inverted papilloma. After the capture and print of corresponding data of each slide, the largest and smallest diameters of the nuclei were measured and the morphometric variables were calculated: average diameter, perimeter, ratio between largest and smallest diameter, volume, area, ratio of volume to area, form coefficient, contour index, and eccentricity.

Results We found a significant difference (p < 0.05) between the two groups in the following morphometric variables: largest diameter, smallest diameter, average diameter, volume, area, perimeter, and ratio of volume to area, indicating that these parameters can be useful in diagnostic differentiation between these diseases.

Conclusion We founded morphometric variables higher in patients with inverted papilloma, which can be related to the neoplastic origin of the inverted papilloma. The analysis of nuclear parameters is an instrument of great value in the differential diagnosis between rhinosinusal polyposis and inverted papilloma.

Keywords

nasal polyps - papilloma - inverted - nasal cavity - otorhinolaryngologic neoplasms
 

  • References

  • 1 Gelardi M, Iannuzzi L, Tafuri S, Passalacqua G, Quaranta N. Allergic and non-allergic rhinitis: relationship with nasal polyposis, asthma and family history. Acta Otorhinolaryngol Ital 2014; 34 (1) 36-41
    Search in Google Scholar
  • 2 Milara J, Peiró T, Armengot M , et al. Mucin 1 downregulation associates with corticosteroid resistance in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 2014;
    Search in Google Scholar
  • 3 Souza BB, Sierra MF, Dorgam JV , et al. Polipose nasossinusal: doença inflamatoria cronica evolutiva?. Rev Bras Otorrinolaringol 2003; 69 (3) 318-325
    CrossrefSearch in Google Scholar
  • 4 Settipane GA. Epidemiology of nasal polyps. Allergy Asthma Proc 1996; 17 (5) 231-236
    CrossrefSearch in Google Scholar
  • 5 Haetinger RG. Evaluation by image of the paranasal sinuses in correlation with endoscopy and endoscopic surgery endonasal. Rev Bras Otorrinolaringol 1998; 64 (2) 17-29
    Search in Google Scholar
  • 6 Garavello W, Gaini RM. Incidence of inverted papilloma in recurrent nasal polyposis. Laryngoscope 2006; 116 (2) 221-223
    CrossrefSearch in Google Scholar
  • 7 Garavello W, Gaini RM. Histopathology of routine nasal polypectomy specimens: a review of cases 2147. Laryngoscope 2005; 115 (10) 1866-1868
    CrossrefSearch in Google Scholar
  • 8 Vicenti AB, Takano ER, Ísola EMB , et al. Inverted papilloma: experience and surgical treatment. Rev Bras Otorrinolaringol 2001; 67 (5) 702-705
    CrossrefSearch in Google Scholar
  • 9 Laitakari J, Harrison D, Stenbäck F. Morphometric characteristics of cell proliferation and p53 expression in development of experimentally induced respiratory tumors. Anal Quant Cytol Histol 2001; 23 (4) 273-286
    Search in Google Scholar
  • 10 Lacerda CAM. Stereological tools in biomedical research. An Acad Bras Ciênc 2003; 75 (4) 469-486
    Search in Google Scholar
  • 11 Bartels PH, Montironi R, Scarpelli M, Bartels HG, Alberts DS. Knowledge discovery processing and data mining in karyometry. Anal Quant Cytol Histol 2009; 31 (3) 125-136
    Search in Google Scholar
  • 12 Fernández-López F, Paredes-Cotoré JP, Cadarso-Suárez C, Forteza-Vila J, Puente-Domínguez JL, Potel-Lesquereux J. Prognostic value of nuclear morphometry in colorectal cancer. Dis Colon Rectum 1999; 42 (3) 386-392
    CrossrefSearch in Google Scholar
  • 13 Reifen E, Noyek AM, Mullen JB. Nuclear morphometry and stereology in nasopharyngeal carcinoma. Laryngoscope 1992; 102 (1) 53-55
    Search in Google Scholar
  • 14 Matos MA, Martins AT, Azoubel R. Effects of sodium cyclamate on the rat placenta: a morphometric study. Int J Morphol 2006; 24 (2) 137-142
    Search in Google Scholar
  • 15 Leme FAGL, Azoubel R. Effects of aspartame on the exocrine pancreas of rat fetuses. Int J Morphol 2006; 24 (4) 679-684
    Search in Google Scholar
  • 16 Pereira KD, Leyden P, Miller ACML. Anaplastic carcinoma of the paranasal sinuses presenting as a nasal polyp. Ulster Med J 1993; 62 (1) 98-100
    Search in Google Scholar