Facial plast Surg 2015; 31(02): 152-159
DOI: 10.1055/s-0035-1549284
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Dynamic Change of Myogenin in Denervated Rat Mimetic Muscle

Takehiro Warabi1, Hiroshi Furukawa1, Ryuji Shichinohe1, Toshihiko Hayashi1, Yuhei Yamamoto1
  • 1Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido, Sapporo, Japan
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Publication History

Publication Date:
08 May 2015 (online)

Abstract

We previously reported double innervation of rat mimetic muscles with labeling of facial nuclei. However, whether denervated mimetic muscles are affected after such nerve repair is not known. Rats were divided into five groups: Group A, controls; Group B, complete facial palsy; Group C, complete facial palsy with repair using end-to-end neurorrhaphy; Group D, incomplete facial palsy; and Group E, incomplete facial palsy with repair using end-to-side neurorrhaphy. Preoperatively and postoperatively, facial palsy and myogenin (Myog) expression in mimetic muscles were evaluated. Expression peaked on day 7 in Group B but was lower in Groups C and D. Expression in Groups D and E was comparable on day 28, and each model's score showed characteristic changes. Myog expression in facial mimetic muscles increases with denervation and decreases with nerve repair. Determining Myog expression levels in mimetic muscles just after nerve repair may help surgeons predict postoperative prognosis in facial palsy.

Disclosure

This work was supported by a grant-in-aid for exploratory research from the Japanese Ministry of Education, Culture, Sports, Science and Technology (10001881).