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J Pediatr Genet 2015; 04(02): 056-070
DOI: 10.1055/s-0035-1556740
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Prescription Opioids in Pregnancy and Birth Outcomes: A Review of the Literature

Mahsa M. Yazdy
1   Slone Epidemiology Center at Boston University, Boston, Massachusetts, United States
,
Rishi J. Desai
2   Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States
,
Susan B. Brogly
3   Department of Medicine and Surgery, Queen's University, Kingston, Ontario, Canada
› Author Affiliations
Further Information

Publication History

30 January 2015

05 February 2015

Publication Date:
31 July 2015 (online)

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Abstract

Prescription opioids are used prenatally for the management of pain, as well as for opiate dependency. Opioids are known to cross the placenta and despite the evidence of possible adverse effects on fetal development, studies have consistently shown prescription opioids are among the most commonly prescribed medications and the prevalence of use is increasing among pregnant women. This article summarizes the available literature documenting potential harms associated with prescription opioid use during pregnancy, including poor fetal growth, preterm birth, birth defects, and neonatal abstinence syndrome.

Keywords

opioids - pregnancy - fetal growth - birth weight - birth defects - neonatal abstinence syndrome
 

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