Micro-RNA in der Pathogenese rheumatischer Erkrankungen

• Literatur

• 1 Kuchen S, Resch W, Yamane A et al. Regulation of microRNA expression and abundance during lymphopoiesis. Immunity 2010; 32: 828-839
• 2 Frank-Bertoncelj M, Gay S. The epigenome of synovial fibroblasts: an underestimated therapeutic target in rheumatoid arthritis. Arthritis Res Ther 2014; 16: 117
• 3 Filkova M, Jungel A, Gay RE et al. MicroRNA in rheumatoid arthritis: potential role in diagnosis and therapy. BioDrugs 2012; 26: 131-141
• 4 Vettori S, Gay S, Distler O. Role of MicroRNAs in Fibrosis. Open Rheumatol J 2012; 6: 130-139
• 5 Stanczyk J, Pedroli DM, Brentano F et al. Altered expression of microRNA in the synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum 2008; 58: 1001-1009
• 6 Kurowska-Stolarska M, Alivernini S, Ballantine LE et al. MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc Natl Acad Sci USA 2011; 108: 11193-11198
• 7 Stanczyk J, Ospelt C, Karouzakis E et al. Altered expression of miR-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis Rheum 2011; 63: 373-381
• 8 Brock M, Trenkmann M, Gay RE et al. MicroRNA-18a enhances the IL-6 mediated production of the acute-phase proteins fibrinogen and haptoglobin in human hepatocytes. J Biol Chem 2011; 286: 40142-40150
• 9 Trenkmann M, Brock M, Gay RE et al. The TNFα-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling. Arthritis Rheum 2013; 65: 916-927
• 10 Kurinna S, Schäfer M, Ostano P et al. A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes. Nat Commun 2014; 5: 5099
• 11 Brock M, Samillan VJ, Trenkmann M et al. AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension. Eur Heart J 2014; 35: 3203-3211