MnO₂-Catalyzed Oxidative Alkylation of Enamides with Ethers via C(sp³)–H/C(sp²)–H Cross-Dehydrogenative Coupling and Hydrolysis Sequence

Abstract

A new MnO₂-catalyzed oxidative alkylation of enamides with a C(sp³)–H bond adjacent to an oxygen atom is described. This method achieves a C(sp³)-H/C(sp²)-H cross-dehydrogenative coupling and hydrolysis, thus providing efficient and general access to a variety of β-oxo ketones.

Key words

C(sp³)–H/C(sp²)–H cross-dehydrogenative coupling - ethers - enamides - β-oxo ketones - radicals

• References and Notes


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