The squaramide moiety has proven to be a powerful hydrogen-bonding donor in organocatalysis,
but chiral phase-transfer catalysts bearing the squaramide motif have not been reported
so far. Reported herein is this kind of catalyst and their catalytic performance in
the asymmetric fluorination of β-keto esters.
Key words
organocatalysis - phase-transfer catalysis - asymmetric catalysis - fluorination
- squaramides