Acid-Free Silver-Catalyzed Cross-Dehydrogenative Carbamoylation of Pyridines with Formamides

Wei Han; Fengli Jin; Qian Zhao; Hongyan Du; Lifang Yao

doi:10.1055/s-0035-1561975

Synlett, Inhaltsverzeichnis

Synlett 2016; 27(12): 1854-1859
DOI: 10.1055/s-0035-1561975

letter

Acid-Free Silver-Catalyzed Cross-Dehydrogenative Carbamoylation of Pyridines with Formamides

Autoren

Wei Han*

^aJiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road NO.1, Nanjing 210023, P. R. of China eMail: whhanwei@gmail.com

^bJiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing 210023, P. R. of China
Fengli Jin

^aJiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road NO.1, Nanjing 210023, P. R. of China eMail: whhanwei@gmail.com
Qian Zhao

^aJiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road NO.1, Nanjing 210023, P. R. of China eMail: whhanwei@gmail.com
Hongyan Du

^aJiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road NO.1, Nanjing 210023, P. R. of China eMail: whhanwei@gmail.com
Lifang Yao

^aJiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road NO.1, Nanjing 210023, P. R. of China eMail: whhanwei@gmail.com

Abstract

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Abstract

Primary pyridylcarboxamides are prevalent parent structures in bioactive molecules and have the apparent advantages over N-protected derivatives as synthetic building blocks. However, no practical methods have been developed for direct synthesis of this compound class from unfunctionalized pyridines. We herein present a general, safe, concise, acid-free, and highly selective method for the C2-carbamoylation of pyridines with unprotected formamide and N-methyl formamide through the cleavage of two C–H bonds.

Key words

pyridylcarboxamides - pyridines - C–H bonds functionalization - carbamoylation - formamides

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Referenzen

References and Notes

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