CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2018; 37(03): 239-241
DOI: 10.1055/s-0036-1578569
Case Report | Relato de Caso
Thieme Publicações Ltda Rio de Janeiro, Brazil

Surgical Treatment of Rosai-Dorfman Intracranial Disease: Case Report and Literature Review

Article in several languages: English | português
Klisman Drescher Hilleshein
1   Medical Student, Universidade do Oeste de Santa Catarina, Joaçaba, SC, Brazil
Vinícius Galisteo Santin
1   Medical Student, Universidade do Oeste de Santa Catarina, Joaçaba, SC, Brazil
Fabrício Molon da Silva
2   Neurosurgeon, Hospital Universitário Santa Terezinha, Joaçaba, SC, Brazil
› Author Affiliations
Further Information

Publication History

04 July 2015

07 January 2016

Publication Date:
09 March 2016 (online)


Rosai-Dorfman disease is a benign lymphoproliferative disease with rare occurrence in the overall population. The characteristic findings of the disease are emperipolesis on microscopy and S-100 protein positivity on immunohistochemistry. The present report describes the case of a 57-year-old man who presented with repeated seizures, urinary retention, and ataxia. Satisfactory results were obtained with surgical treatment. The diagnosis was confirmed by immunohistochemistry.

  • References

  • 1 Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol 1969; 87 (01) 63-70
  • 2 Warrier R, Chauhan A, Jewan Y, Bansal S, Craver R. Rosai-Dorfman disease with central nervous system involvement. Clin Adv Hematol Oncol 2012; 10 (03) 196-198
  • 3 Mahzoni P, Zavareh MHT, Bagheri M, Hani N, Moqtader B. Intracranial ROSAI-DORFMAN Disease. J Res Med Sci 2012; 17 (03) 304-307
  • 4 Adeleye AO, Amir G, Fraifeld S, Shoshan Y, Umansky F, Spektor S. Diagnosis and management of Rosai-Dorfman disease involving the central nervous system. Neurol Res 2010; 32 (06) 572-578
  • 5 Sameshima T, Morita A, Tanikawa R, Tsuboi T, Kitai R. Isolated Intracranial Rosai-Dorfman Disease Mimicking Convexity Menin- gioma: A Case Report. J Clin Exp Pathol 2012; 2 (05) 2-5
  • 6 Konishi E, Ibayashi N, Yamamoto S, Scheithauer BW. Isolated intracranial Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy). AJNR Am J Neuroradiol 2003; 24 (03) 515-518
  • 7 Chen S-C, Teo B-T, Yen P-S. Isolated Intracranial Rosai-Dorfman Disease: Report of 2 Cases and Review of the Literature. Tzu Chi Med J. 2007; 19 (02) 90-93
  • 8 Cooper SL, Jenrette JM. Rosai-Dorfman disease: management of CNS and systemic involvement. Clin Adv Hematol Oncol 2012; 10 (03) 199-202
  • 9 Baildam EM, Ewing CI, D'Souza SW, Stevens RF. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): response to acyclovir. J R Soc Med 1992; 85 (03) 179-180
  • 10 Melo-Souza SE. Tratamento das doenças neurológicas. Rio de Janeiro: Guanabara Koogan; 2000