Synlett
DOI: 10.1055/s-0036-1588531
letter
© Georg Thieme Verlag Stuttgart · New York

β-Lactam-Synthon-Interceded Metal/Acid-Free Diastereoselective Access to Highly Functionalized Oxazol-5-ones and Dihydroimidazoles

Amandeep Singha, Shalini, a, Harleen Kaura, Palak Sharmaa, Amit Anandb, Vipan Kumar*a
  • aDepartment of Chemistry, Guru Nanak Dev University, Amritsar 143005, India   Email: vipan_org@yahoo.com
  • bDepartment of Chemistry, Khalsa College, Amritsar 143005, India
A.A. wishes to thank the University Grants Commission, New Delhi, India for financial support under grant no. ROMRP-NRCB-CHEM-2015-16-87198
Further Information

Publication History

Received: 22 May 2017

Accepted after revision: 11 July 2017

Publication Date:
11 August 2017 (eFirst)

Abstract

Facile diastereoselective access to functionalized oxazol-5-ones and dihydroimidazoles was accomplished through base-promoted intramolecular amidolysis and methoxide-assisted tandem intramolecular amidolysis/ring opening/intramolecular cyclization, respectively, of C-3-functionalized azetidin-2-ones.

Supporting Information