Synlett
DOI: 10.1055/s-0036-1588568
cluster
© Georg Thieme Verlag Stuttgart · New York

Chromium-Catalyzed, Regioselective Cross-Coupling of C–O Bonds by Using Organic Bromides as Reactants

Jinghua Tanga, b, Meiming Luo*a, Xiaoming Zeng*a, b
  • aKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. of China
  • bFrontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710054, P. R. of China   Email: luomm@scu.edu.cn   Email: zengxiaoming@mail.xjtu.edu.cn
We thank the National Natural Science Foundation of China, SCU, and Beijing National Laboratory for Molecular Sciences for financial support.
Further Information

Publication History

Received: 01 July 2017

Accepted after revision: 22 August 2017

Publication Date:
14 September 2017 (eFirst)

Published as part of the Cluster C–O Activation

Abstract

We report a chromium-catalyzed cross-coupling of C–O bonds with widely accessible organic bromides as reactants for the preparation of ortho-arylated or -alkylated aromatic aldehydes at room temperature. The use of metallic magnesium is essential for the reaction to occur, giving it an advantage over previous reactions involving Grignard reagents that have to be prepared separately from organic halides before the coupling.

Supporting Information