Chromium-Catalyzed, Regioselective Cross-Coupling of C–O Bonds by Using Organic Bromides as ReactantsWe thank the National Natural Science Foundation of China, SCU, and Beijing National Laboratory for Molecular Sciences for financial support.
Received: 01 July 2017
Accepted after revision: 22 August 2017
14 September 2017 (eFirst)
Published as part of the Cluster C–O Activation
We report a chromium-catalyzed cross-coupling of C–O bonds with widely accessible organic bromides as reactants for the preparation of ortho-arylated or -alkylated aromatic aldehydes at room temperature. The use of metallic magnesium is essential for the reaction to occur, giving it an advantage over previous reactions involving Grignard reagents that have to be prepared separately from organic halides before the coupling.