Synlett
DOI: 10.1055/s-0036-1589099
letter
© Georg Thieme Verlag Stuttgart · New York

Symmetrical Trichlorotriazine Derivatives as Efficient Reagents for One-Pot Synthesis of 3-Acetyl-2-chloroquinolines from Acetanilides under Vilsmeier–Haack Conditions

Bhooshan Muddam, P. Venkanna, M. Venkateswarlu, M. Satish Kumar, K. C. Rajanna*
  • Department of Chemistry, Osmania University, Hyderabad-500 007, T. S., India   Email: kcrajannaou@yahoo.com
Further Information

Publication History

Received: 11 June 2017

Accepted after revision: 28 August 2017

Publication Date:
28 August 2017 (eFirst)

Abstract

Symmetrical trichlorotriazine derivatives such as 2,4,6-trichloro-1,3,5-triazine and trichloroisocyanuric acid were explored as Vilsmeier–Haack type reagents in the presence of N,N-dimethylacetamide for the effective synthesis of 3-acetyl-2-chloroquinolines from acetanilides. Ultrasonication led to shorter reaction times than conventional heating and gave yields comparable to those obtained under reflux conditions.

Supporting Information