Abstract
We have developed copper-promoted oxidative carbon–carbon bond-forming reactions
to synthesize α-aryl carbonyl compounds. The use of weak C–H acids as nucleophiles
under Chan–Evans–Lam-type conditions enables α-arylation reactivity complementary
to that of established copper- or palladium-catalyzed cross-coupling methodologies
that employ aryl (pseudo)halides. This Synpacts article will discuss key observations
and experimental parameters that allowed for reaction development, substrate scope
studies, and applications in bioactive molecule synthesis and functionalization.
1 Introduction
2 Oxidative Cross-Coupling of Activated Methylenes and Organoboron Reagents
3 Decarboxylative Oxidative Arylation of Malonic Acid Derivatives
4 Conclusion
Key words
aerobic catalysis - arylation - boron - copper - cross-coupling
