Synlett 2017; 28(16): 2066-2092
DOI: 10.1055/s-0036-1590854
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© Georg Thieme Verlag Stuttgart · New York

Chemistry 2.0: Developing a New, Solvent-Free System of Chemical Synthesis Based on Mechanochemistry

Jean-Louis Do
Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montréal, Québec, H3A 0B8, Canada   Email: [email protected]
,
Tomislav Friščić*
Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montréal, Québec, H3A 0B8, Canada   Email: [email protected]
› Author Affiliations
We acknowledge the financial support of the NSERC Discovery Grant (grant no. NSERC RGPIN-2017-06467), the NSERC E. W. R. Steacie ­Memorial Fellowship (T.F.) and the McGill University W. J. Dawson Scholar­ship (T.F.)
Further Information

Publication History

Received: 15 May 2017

Accepted after revision: 03 July 2017

Publication Date:
17 August 2017 (online)


Abstract

Mechanochemistry by grinding or milling has grown from a laboratory curiosity to a versatile approach for the synthesis and discovery of molecules, materials and reactivity. Focusing on organic synthesis and the chemistry of organic solids in general, we now provide a snapshot of this exciting, rapidly developing area, with the intention to illustrate its potential in establishing a more efficient and environmentally friendly system of chemical and materials synthesis, based on solid-state transformations rather than conventional, solution-dependent chemistry.

1 What is Chemistry 2.0?

2 Introduction

2.1 Why Mechanochemistry Now?

2.2 What’s in a Mechanochemistry Laboratory?

3 Liquid-Assisted Grinding (LAG): Controlling Mechanochemistry

4 The Solvent-Free Research Laboratory

5 Medicinal Mechanochemistry

6 Exploring Molecular Recognition

7 Some Myths to Dispel

8 Catalytic Reactions by Mechanochemistry

8.1 Catalysis and Reactivity Involving Bulk Metals

8.2 Enzyme Catalysis in Mechanochemistry

8.3 Coupling of Mechanochemistry, Photochemistry and Supramolecular Catalysis

9 Organometallic Mechanochemistry

10 New Opportunities

10.1 Stoichiometric Control

10.2 ‘Impossible’ Molecules

10.3 Reaction Discovery by Mechanochemistry

11 Energetics of Mechanochemistry

12 Mechanistic Understanding

13 Real-Time Reaction Monitoring

14 Conclusions

 
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