Synlett
DOI: 10.1055/s-0036-1590902
cluster
© Georg Thieme Verlag Stuttgart · New York

A Quantitative NMR Method for Silyllithium Analysis

Yingjian Bo, Scott McN. Sieburth*
  • Department of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, Pennsylvania 19122, USA   Email: scott.sieburth@temple.edu
This work was supported by the National Institute of General Medical Sciences (grant number R01GM076471).
Further Information

Publication History

Received: 14 August 2017

Accepted after revision: 17 August 2017

Publication Date:
05 September 2017 (eFirst)

Published as part of the Cluster Silicon in Synthesis and Catalysis

Abstract

A rapid and extremely simple method for silyl anion analysis is presented. The progress of silyllithium reagent preparation can be determined by quenching an aliquot with neat chloro(trimethyl)silane, evaporation, dilution with CDCl3, and direct proton NMR analysis. This procedure is fast, simple, and allows for identification and relative quantification of the starting reagent, intermediates, and the silyllithium product.

Supporting Information