Synlett
DOI: 10.1055/s-0036-1590976
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Enaminones by a Palladium-Catalyzed Four-Component Carbonylative Addition Reaction

Liangguang Wang*a, Juan Maa, Xia Chenb, Xiaoyu Zhou*b
  • aCollege of Chemistry and Chemical Engineering, Anshun University, Anshun, 561000, P. R. of China   Email: wang825663@163.com
  • bDepartment of Chemistry and Chemical Engineering, Liupanshui Normal University, Liupanshui, 553004, P. R. of China   Email: zhouxiaoyu20062006@126.com
This work was supported by the Foundation of Science and Technology Department of Guizhou Province (qiankeheJzi [2015] number 2003) and the Doctoral Foundation of Anshun University (asubsjj201501).
Further Information

Publication History

Received: 05 June 2017

Accepted after revision: 03 July 2017

Publication Date:
08 August 2017 (eFirst)

Abstract

A palladium-catalyzed carbonylative addition reaction of aryl bromides, amines, and alkynes has been developed. The reaction ­occurs readily in N,N-dimethylformamide with PdCl2(PPh3)2 as a catalyst to give the corresponding enaminones in medium to excellent yields. Furthermore, a mechanism for the palladium-catalyzed four-component carbonylative addition reaction is proposed.

Supporting Information