Synthesis of Enaminones by a Palladium-Catalyzed Four-Component Carbonylative Addition ReactionThis work was supported by the Foundation of Science and Technology Department of Guizhou Province (qiankeheJzi  number 2003) and the Doctoral Foundation of Anshun University (asubsjj201501).
Received: 05 June 2017
Accepted after revision: 03 July 2017
08 August 2017 (eFirst)
A palladium-catalyzed carbonylative addition reaction of aryl bromides, amines, and alkynes has been developed. The reaction occurs readily in N,N-dimethylformamide with PdCl2(PPh3)2 as a catalyst to give the corresponding enaminones in medium to excellent yields. Furthermore, a mechanism for the palladium-catalyzed four-component carbonylative addition reaction is proposed.